ArticleJournal of experimental botany2026
Fine-mapping, candidate gene identification, and marker development for the apple scab resistance gene Rvi2.
Article in Journal of experimental botany, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Development of an open-pollinated genetic mapping framework to facilitate the identification of QTL in apples.The plant genome · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Breeding elite apple cultivars with scab resistance is a key global goal, as reliance on fungicides is unsustainable. The causal fungus, Venturia inaequalis, evolves rapidly, threatening cultivars with single-gene resistance. Since the 1980s, breeding programmes have introduced novel resistance sources via backcrossing. Here, we generated a haplotype-phased genome assembly of Russian apple R12740-7A and an Oxford Nanopore assembly of the Rvi2-resistance accession TSR34T15, enabling detailed dissection of the Rvi2 resistance locus. Fine-mapping using a 'Royal Gala' × TSR34T15 segregating family delimited Rvi2 to a narrow genomic interval, within which we identified a 10 041 bp long terminal repeat retrotransposon (LTR-RT) insertion-an insert-based structural variant (SV) strongly linked with Rvi2. Notably, this LTR-RT harbours an FPPS gene, a member of the farnesyl pyrophosphate/geranylgeranyl pyrophosphate (FPP/GGPP) synthase family, located 2 kb from a key candidate defence gene. Although the FPPS gene exhibits stable expression, its integration within the retrotransposon suggests a cis-regulatory role, potentially priming adjacent defence genes for robust up-regulation upon pathogen attack. We validated the marker derived from this SV in diverse germplasms and successfully implemented it in marker-assisted selection across extensive seedling cohorts. This marker will streamline the development of scab-resistant apple varieties.
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