ReviewCancer science2026
Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone.
Review in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
Abstract
Decades of research into the immune regulation of cancer have revolutionized oncology, leading to the clinical success of immune checkpoint inhibitors. In contrast, the roles of nonimmune systems in tumor regulation remain largely undefined. Our recent study of cancer bone invasion has uncovered a previously unrecognized host defense mechanism: stromal cells in the periosteum, the membranous tissue enveloping the bone, actively respond to tumor proximity and facilitate periosteum thickening that physically impedes tumor invasion into the bone. We propose a new concept, "stromal defense against cancer (SDAC)," a unique mechanism of tumor regulation orchestrated by stromal cells. In this review, we summarize the molecular and cellular mechanisms underlying SDAC and discuss its clinical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.