Evidence map›Paper›PMID 41276060›Full record

ArticleDevelopmental biology2026

Cranial neural crest shortage leads to extensive craniofacial anomalies in mice mutant for the NR2F1/2 nuclear receptors.

David Paulding, Simon J Y Han, Jonathan Timmons, Michelle Caye, Alexa Riedel, Samantha A Brugmann, Lindsey Barske

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David PauldingDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Simon J Y HanDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Jonathan TimmonsDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Michelle CayeDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Alexa RiedelDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Samantha A BrugmannDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA; Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
Lindsey BarskeDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA. Electronic address: lindsey.barske@cchmc.org.

Funding

Prolonger progenitor maintenance sculpts the upper faceR00DE026239 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI BARSKE, LINDSEY ANNE · 2019 to 2021
$744k
Prolonged Progenitor Maintenance Sculpts the Upper FaceK99DE026239 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARSKE, LINDSEY ANNE · 2016 to 2017
$252k
Developmental roles of Nr2f1 and Nr2f2 in the vertebrate cranial neural crestF31DE032261 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI PAULDING, DAVID · 2022 to 2024
$125k
NIDCR NIH HHS F31 DE032261NIDCR NIH HHS K99 DE026239NIDCR NIH HHS R00 DE026239
6 · The paper itself

Abstract

Nuclear receptors are iteratively deployed during neural crest development, from pre-induction through differentiation stages. NR2F1 and NR2F2 in particular have been proposed as broad regulators of early neural crest gene expression in mammals, but the timing, extent, and redundancy of their developmental requirement has remained unclear, as Nr2f1 and Nr2f2 single mouse mutants present only minimal craniofacial phenotypes. Here we report the dynamic expression patterns of Nr2f1 and Nr2f2 in the mouse cranial neural crest from specification through post-migratory stages. Combined conditional knockout of both Nr2f1 and Nr2f2 in the neural crest with Wnt1-Cre or Pax3

Indexed as

COUP Transcription Factor ICOUP Transcription Factor IICraniofacial AbnormalitiesNeural CrestSkullAnimalsCell MovementGene Expression Regulation, DevelopmentalMiceMice, KnockoutMutationPhenotypeCOUP Transcription Factor ICOUP Transcription Factor IINr2f1 protein, mouseCranial neural crestCraniofacialNr2f1Nr2f2Pax3(Cre)Wnt1-cre

Identifiers

PMID41276060
PMCPMC12720995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.