Evidence map›Paper›PMID 41275764›Full record

ArticleEnvironment international2025

Microplastic exposure elicits sex-specific atherosclerosis development in lean low-density lipoprotein receptor-deficient mice.

Ting-An Lin, Jianfei Pan, Mya Nguyen, Qianyi Ma, Liang Sun, Sijie Tang, Matthew J Campen, Hong Chen, Changcheng Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ting-An LinDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA.
Jianfei PanDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA.
Mya NguyenDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA.
Qianyi MaResearch Informatics, Department of Information Technology, Boston Children's Hospital, Boston, MA, USA.
Liang SunResearch Informatics, Department of Information Technology, Boston Children's Hospital, Boston, MA, USA.
Sijie TangDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA.
Matthew J CampenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences, Albuquerque, NM, USA.
Hong ChenVascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Changcheng ZhouDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA. Electronic address: changcheng.zhou@ucr.edu.

Funding

Role of PXR in EDC-induced cardiovascular diseaseR35ES035015 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Changcheng Zhou · 2023 to 2026
$3.4M
Role of PXR in drug-elicited cardiovascular diseaseR01HL167206 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Hong Chen, Changcheng Zhou · 2023 to 2026
$2.8M
NHLBI NIH HHS R01 HL167206NIEHS NIH HHS R35 ES035015
6 · The paper itself

Abstract

Microplastics (MPs) are small plastic particles emerging as significant environmental pollutants and humans are ubiquitously exposed to MPs. MPs can be detected in human atherosclerotic plaques and are associated with a higher risk of cardiovascular disease (CVD) and stroke in humans. However, the impact of MP exposure on the cardiovascular system remains elusive. In the current study, we investigated the effects of exposure to MPs at an environmentally relevant dose on atherosclerosis development in male and female low-density lipoprotein receptor-deficient (LDLR

Indexed as

AtherosclerosisEnvironmental PollutantsMicroplasticsReceptors, LDLAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutSex FactorsEnvironmental PollutantsMicroplasticsReceptors, LDLAtherosclerosisCardiovascular diseaseEndothelial cell dysfunctionMicroplasticsSingle-cell RNA sequencing

Identifiers

PMID41275764
PMCPMC13321909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.