Evidence map›Paper›PMID 41275521›Full record

ArticleGenes, brain, and behavior2025

Sex-Specific, Intermediate Behavioral Phenotypes in Heterozygous Dopamine Transporter Mutant DAT T356M Mice.

Emma Harris, Krista C Paffenroth, Adriana A Tienda, Fiona E Harrison, Mark T Wallace

Abstract read
In one paragraph

Article in Genes, brain, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emma HarrisVanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee, USA.
Krista C PaffenrothDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
Adriana A TiendaDivision of Diabetes & Endocrinology & Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Fiona E HarrisonDivision of Diabetes & Endocrinology & Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mark T WallaceDepartment of Psychology, Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee, USA.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Manganese exposure and genetic diversity in risk mechanisms for neurodevelopmental disordersR01ES035518 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOWMAN, AARON B, HARRISON, FIONA EDITH · 2024 to 2025
$3.6M
NICHD NIH HHS P50 HD103537NIEHS NIH HHS R01 ES035518
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with both genetic and environmental contributions. Previous work identified a de novo mutation in the dopamine transporter (DAT T356M) in an autism proband that results in profound behavioral changes when expressed homozygously in mice. Since complex human genetics are more likely to be present as heterozygous (single allele) mutations, we characterized mice that were heterozygous for the mutation. Both male and female DAT T356M

Indexed as

Autism Spectrum DisorderBehavior, AnimalDopamine Plasma Membrane Transport ProteinsAnimalsFemaleHeterozygoteMaleMaze LearningMiceMice, Inbred C57BLMutationPhenotypePrepulse InhibitionReflex, StartleSensory GatingSex CharacteristicsDopamine Plasma Membrane Transport ProteinsSlc6a3 protein, mouseautism spectrum disorderbehaviordopamine transportermouse modelsex differences

Identifiers

PMID41275521
PMCPMC12640684

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.