Evidence map›Paper›PMID 41275496›Full record

ArticleCell reports2025

Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus.

Seung Chul Choi, Yong Ge, Ahmed Elshikha, Yuk Pheel Park, Cenxiao Fang, Milind V Joshi, Maria Montes de Oca Arena, Lauren Padilla, Yanan Zhu, William L Clapp and 3 more

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Seung Chul ChoiDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Yong GeDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Ahmed ElshikhaDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
Yuk Pheel ParkDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Cenxiao FangDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Milind V JoshiDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Maria Montes de Oca ArenaDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Lauren PadillaDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Yanan ZhuDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
William L ClappDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
Eric S SobelDepartment of Medicine, University of Florida, Gainesville, FL 32610, USA.
Mansour MohamadzadehDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, San Antonio, TX 78229, USA. Electronic address: zadehm@uthscsa.edu.
Laurence MorelDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA. Electronic address: morel@uthscsa.edu.

Funding

Determinants of follicular helper T cell expansion in lupusR01AI154630 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MOREL, LAURENCE, ZADEH, MANSOUR M · 2020 to 2025
$6.3M
South Texas Medical Scientist Training Program (STX-MSTP)T32GM145432 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jose E Cavazos, Ratna K Vadlamudi · 2023 to 2026
$2.3M
Targeting follicular helper CD4 T cells in SLER37AI128901 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Laurence Morel · 2022 to 2026
$2.3M
Targeting follicular helper CD4 T cells in SLER01AI128901 · NIAID · UNIVERSITY OF FLORIDA · PI MOREL, LAURENCE · 2017 to 2021
$1.8M
South Texas Medical Scientist Training Program (STX-MSTP)T32GM113896 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CAVAZOS, JOSE E · 2018 to 2022
$1.1M
BLRD VA I01 BX006310NIAID NIH HHS R01 AI128901NIAID NIH HHS R01 AI154630NIAID NIH HHS R37 AI128901NIGMS NIH HHS T32 GM113896NIGMS NIH HHS T32 GM145432
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the production of pathogenic autoantibodies depends on T follicular helper (T

Indexed as

Cellular ReprogrammingDeoxyglucoseGlycolysisLupus Erythematosus, SystemicT Follicular Helper CellsAnimalsAutoantibodiesFemaleHumansMiceMice, Inbred C57BLAutoantibodiesDeoxyglucoseautophagyCP: immunologyCP: metabolismfollicular helper T cellsglycolysislupusmitochondria

Identifiers

PMID41275496
PMCPMC12812013

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.