Evidence map›Paper›PMID 41275495›Full record

ArticleCell reports2025

Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity.

Kyle D Dumont, Saba Heydari Seradj, Yu Wang, Shanshan Liu, Igor Cervenka, Chao Wu, Paulo R Jannig, Margareta Porsmyr-Palmertz, Gerard Baiges-Gaya, Xun Huang and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Kyle D DumontMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Saba Heydari SeradjHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.
Yu WangHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.
Shanshan LiuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Igor CervenkaMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Chao WuStanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Paulo R JannigMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Margareta Porsmyr-PalmertzMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Gerard Baiges-GayaMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Xun HuangHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.
Carina NihlenPharmacological Nitric Oxide Research, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
José M DiasNanomedicine and Spatial Biology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Simona S SkiotyteMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Stine Marie PræstholmMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Dawn WilbertDepartment of Pharmacology and Stanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Aurel B LeuchtmannDepartment of Pharmacology and Stanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Melissa A QuinnDepartment of Pharmacology and Stanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ziming ZhuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Chelsea HeplerDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Jon O LundbergPharmacological Nitric Oxide Research, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Ana I TeixeiraNanomedicine and Spatial Biology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Anthony RosenzweigStanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jun WuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Li YeHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.
Jorge L RuasMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Pharmacology and Stanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: jlruas@med.umich.edu.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular LevelR35HL155318 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANTHONY ROSENZWEIG · 2021 to 2026
$5.4M
The role of immune-adipocyte cholinergic signaling during metabolic adaptation and dysfunctionR01DK107583 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WU, JUN · 2016 to 2024
$3.4M
Modulating somatosensory network to target metabolic diseasesDP2DK128800 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI YE, LI · 2020 to 2020
$2.7M
NHLBI NIH HHS R35 HL155318NIDDK NIH HHS DP2 DK128800NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK107583
6 · The paper itself

Abstract

Communication between the brain and adipose tissue is mediated in part by the peripheral nervous system. The sympathetic branch transmits lipolytic and thermogenic signals toward adipose tissue, while sensory nerves relay information to the central nervous system. Importantly, sensory nerve activation also triggers local neuropeptide release. Here, we show that sensory-neuron-derived α-calcitonin gene-related peptide (CGRPα) inhibits white, but not brown, preadipocyte differentiation in a cell-autonomous manner. In vivo, CGRPα expression in mouse subcutaneous adipose tissue during cold exposure shifts the expected increase in smaller adipocytes to an increase in larger cells. Importantly, people on anti-CGRPα/CGRP receptor (CGRPR) medications for migraine treatment show reductions in weight and glycemia, while these measures increase in the matched control group. Similarly, mice treated with a CGRPR antagonist and exposed to cold show a reduction in body weight. These findings identify a neuron-adipocyte communication pathway that regulates white adipose tissue plasticity and metabolism.

Indexed as

Adipocytes, WhiteCalcitonin Gene-Related PeptideCell DifferentiationSensory Receptor CellsAdipose Tissue, WhiteAnimalsCold TemperatureHumansMaleMiceMice, Inbred C57BLReceptors, Calcitonin Gene-Related PeptideCalcitonin Gene-Related PeptideReceptors, Calcitonin Gene-Related Peptideadipogenesisadipose tissuecalcitonin gene-related peptideCGRPCP: metabolismCP: neuroscienceinter-organ communicationmetabolismneuron-adipocytesensory neuronsomatosensory innervation

Identifiers

PMID41275495
PMCPMC13189246

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.