ArticleAesthetic plastic surgery2026
Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats.
Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Microneedling-assisted Panax ginseng exosome protocol for vulvovaginal symptoms and vulvar skin tone changes: A preliminary pilot observational study.Women's health (London, England)Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn genitourinary syndrome of menopause (GSM), reduced estrogen levels cause several pathological changes in the vaginal mucosa, including epithelial thinning, decreased blood flow and glycogen production, loss of elasticity, and mucus production. Umbilical cord mesenchymal stem cell-derived exosomes (ucMSC-ex) facilitate intercellular communication and play a key role in mucosal regeneration and immune response modulation.
objectivesWe examined the therapeutic effect of ucMSC-ex injection on vaginal atrophy in ovariectomized rats.
methodsTangential flow filtration was used to extract ucMSC-ex. Female Sprague-Dawley rats were divided into three groups: a group receiving sham treatment, a group receiving sham treatment after ovariectomy, and a group receiving vaginal ucMSC-ex injection after ovariectomy. Treatment efficacy was determined by analyzing rat vaginal tissue to observe changes in the vaginal epithelium and in collagenesis, angiogenesis, estrogen receptor count, vaginal lubrication, and inflammatory response.
resultsOur preliminary histological results indicated that ucMSC-ex injection enhanced structural restoration, collagen formation, angiogenesis, estrogen receptor expression, vaginal lubrication, cellular proliferation, and anti-inflammatory response in vaginal tissue, indicating its regenerative potential as a treatment for GSM.
conclusionsOur findings support the therapeutic potential of exosome therapy in alleviating the symptoms of GSM by promoting tissue regeneration and vascularization, restoring vaginal lubrication, and reducing inflammation. NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.