ArticleArchives of public health = Archives belges de sante publique2025
Vitamin D, premature mortality, and life expectancy among US adults.
Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundVitamin D deficiency is prevailing worldwide and linked to multiple diseases; however, its association with premature mortality remains unknown in the US.
methodsTo investigate the association between serum 25-hydroxyvitamin D or 25(OH)D concentrations and premature mortality and life expectancy in a nationally representative cohort of US adults. We analyzed data of adults aged ≥ 18 years included in the National Health and Nutrition Examination Survey from the Third National Health and Nutrition Examination (NHANES III) (1988 - 1994) and NAHANES (2001 - 2018) with linkage to the National Death Index through December 31, 2019 were investigated. Data were analyzed between July and November in 2024. Serum 25(OH)D was computed as the sum of 25(OH)D3 and 25(OH)D2 concentrations measured by standardized liquid chromatography-tandem mass spectrometry.
resultsTotally 62,704 adults (weighted mean [SE] age: 46.0 [0.19] years; 51.2% women; 26,971 non-Hispanic White adults, 14,228 non-Hispanic Black adults, and 12,436 Mexican American adults) were followed up over a median (IQR) of 12.2 (12.0 to 12.5) years, with 6,323 documented premature deaths. Compared to adults with sufficient 25(OH)D (≥ 75.0 nmol/L), multi-adjusted hazard ratio (HR) was 1.18 (95% confidence interval [CI], 1.07 to 1.30), 1.60 (1.42 to 1.79), and 2.29 (1.92 to 2.72) in those with insufficient (50.0 - 74.9 nmol/L), moderately deficient (25.0 - 49.9 nmol/L), and severely deficient 25(OH)D (< 25.0 nmol/L), respectively (P
conclusionsIn this national cohort, our findings indicated that compared to sufficiency, deficiency, even moderate, in serum 25(OH)D concentrations could correlate with a significantly increased risk of premature mortality and shortened life expectancy, especially among women and White individuals.
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