Evidence map›Paper›PMID 41275206›Full record

ArticleRespiratory research2025

Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling.

Tingmei Feng, Yu Li, Jinmei Wei, Lan Ke, Sen Tan, Liying Luo, Guangnan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tingmei Feng *Department of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Xixiangtang District, Nanning City, Guangxi, 530007, P.R. China.
Yu Li *Department of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Xixiangtang District, Nanning City, Guangxi, 530007, P.R. China.
Jinmei WeiDepartment of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Xixiangtang District, Nanning City, Guangxi, 530007, P.R. China.
Lan KeDepartment of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Xixiangtang District, Nanning City, Guangxi, 530007, P.R. China.
Sen TanDepartment of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Xixiangtang District, Nanning City, Guangxi, 530007, P.R. China.
Liying LuoDepartment of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Xixiangtang District, Nanning City, Guangxi, 530007, P.R. China.
Guangnan LiuDepartment of Respiratory Medicine, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Xixiangtang District, Nanning City, Guangxi, 530007, P.R. China. gnliu63@hotmail.com.

Funding

the Guangxi Key Research and Development Program Grant No. GuiKe AB24010173The Guangxi Natural Science Foundation's Joint Project on Regional High-Incidence Diseases Research Grant No. 2023GXNSFBA026100the National Natural Science Foundation of China Grant No. 82360026
6 · The paper itself

Abstract

Although Th9 cells and their hallmark cytokine IL-9 are implicated in fibrotic diseases, their role in traumatic tracheal stenosis (TS) remains unclear. To clarify their role, we examined Th9 and IL-9 in human and rat models both in vitro and in vivo. First, we observed significantly elevated PU.1, IRF4, and IL-9 expression in patients with TS (n = 10), suggesting enhanced Th9-related immune responses. To assess the functional relevance of this finding, we then employed a rat TS model induced by nylon brush injury and a CD4

Indexed as

Interleukin-9Smad2 ProteinSmad3 ProteinT-Lymphocytes, Helper-InducerTracheal StenosisTransforming Growth Factor beta1AdultAnimalsCells, CulturedDisease Models, AnimalFemaleFibrosisHumansMaleMiddle AgedRatsIL9 protein, humanInterleukin-9Smad2 ProteinSmad2 protein, ratSmad3 ProteinSMAD3 protein, humanSmad3 protein, ratTGFB1 protein, humanTransforming Growth Factor beta1Interleukin-9TGF-β1/SMAD2/3 signalingTh1/Th2 balanceTh9 cellsTraumatic tracheal stenosis

Identifiers

PMID41275206
PMCPMC12715918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.