ArticleWorld journal of surgical oncology2025
Correlation analysis on interaction between Interleukin 10 gene and smoking with esophageal cancer risk in a Chinese Han population.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsThis study aims to evaluate the impact of four SNPs of interleukin-10 (IL- 10) gene, and the interaction with the environmental factors on the risk of esophageal cancer (EC) based on a Chinese Han population.
methodsHardy-Weinberg equilibrium (HWE) and the relationship between four SNPs of IL-10 gene and EC risk was tested using SNPStats online software ( https://www.snpstats.net/start.htm ). Generalized multifactor dimensionality reduction (GMDR) was employed to screen the best interaction combinations among four SNPs, smoking and alcohol drinking.
resultsLogistic regression found that rs1800872-A allele was associated with increased EC risk, ORs (95%CI) was 1.62 (1.19-2.06) for CA genotype and 2.13 (1.48-2.81) for AA genotype, compared to CC genotype, and 1.74 (1.28-2.25) for A allele compared to C allele. We also found that rs1800896- A allele was associated with increased EC risk, ORs (95%CI) was 1.59 (1.24-1.97) for GA genotype and 1.97 (1.36-2.63) for AA genotype, compared to GG genotype, and 1.65 (1.28-2.06) for A allele compared to G allele. GMDR model found a significant gene- environment combination (two-locus model with p = 0.0107) between rs1800896 and smoking. Compared to non- smokers with rs1800896 -GG genotype, smokers with rs1800896- GA + AA genotype of IL- 10 gene have the highest EC risk, OR (95%CI) = 3.76 (1.71-5.83).
conclusionsThe rs1800872-A and rs1800896- A alleles were associated with increased EC risk. Interaction existed between rs1800896 and smoking on EC risk.
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