Evidence map›Paper›PMID 41275162›Full record

ArticleBMC cancer2025

Endoscopic submucosal dissection: a safe alternative to surgical intervention for young patients under 45 years of age with early gastric cancer. ESD vs. surgery in young EGC patients.

Muhammad Haroon Safi, Zhou Hui, Wang Xiaoyong, Liu Bingtuan, Yao Linhua, Wu Bozhi, Qian Haisheng, Yang Zhen, Zhang Guoxin, Wang Yun

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Haroon SafiDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, District of Gulou, Nanjing, 210029, P. R. China.
Zhou HuiDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang XiaoyongDepartment of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.
Liu BingtuanDepartment of Gastroenterology, Jiangyin People's Hospital Affiliated with Nantong University, Jiangyin, Jiangsu, 214400, China.
Yao LinhuaDepartment of Gastroenterology, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, 313000, China.
Wu BozhiDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, District of Gulou, Nanjing, 210029, P. R. China.
Qian HaishengDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, District of Gulou, Nanjing, 210029, P. R. China.
Yang ZhenDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, District of Gulou, Nanjing, 210029, P. R. China.
Zhang GuoxinDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, District of Gulou, Nanjing, 210029, P. R. China. guoxinz@njmu.edu.cn.
Wang YunDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, District of Gulou, Nanjing, 210029, P. R. China. nj_wendy@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic submucosal dissection (ESD) is considered a standard therapy for individuals diagnosed with early gastric cancer (EGC) who demonstrate minimal risk of lymph node metastasis. This study aims to compare the efficacy and safety of ESD for EGC versus surgery for EGC in young patients ≤ 45 years old, assess ESD outcomes and effectiveness across different age groups, and evaluate post-treatment quality of life (QoL) in young patients undergoing ESD or surgery. MATERIALS AND

methodsThis multicenter study retrospectively analyzed data from January 2015 to December 2022, comparing ESD and surgery outcomes, post-treatment QoL in young patients (≤ 45 years), and assessing ESD efficacy across age groups (≤ 45, 46-65, > 65 years).

resultsAmong 154 young patients, 41 underwent ESD, and 113 had surgery, with ESD showing comparable overall survival (OS) 97.6% and disease-free survival (DFS) 97.6% to surgery (OS: 99.1%, DFS: 99.1%) without significant differences (p > 0.05). Across 833 patients who underwent ESD for EGC, ESD demonstrated high efficacy in all age groups, with consistent DFS rates (p = 0.575) and high OS rates (97.6% for ≤ 45, 99.3% for 46-65, 97.6% for > 65). Regarding post-treatment QoL, ESD resulted in fewer complications, such as nausea (p = 0.001) and diarrhea (p = 0.043), than surgery. ESD patients also maintained stable weight and BMI, unlike surgery patients who experienced reductions.

conclusionESD is a safe and effective treatment for EGC in young patients, providing comparable survival outcomes to surgery and offering better post-treatment QoL, which is especially beneficial for young patients due to its effectiveness and favorable impact on QoL.

Indexed as

Endoscopic Mucosal ResectionStomach NeoplasmsAdultAgedAge FactorsFemaleGastrectomyHumansMaleMiddle AgedQuality of LifeRetrospective StudiesTreatment OutcomeYoung AdultAbsolute indicationEarly gastric cancerEndoscopic submucosal dissectionExpanded indicationUndifferentiated expanded indicationYoung patients

Identifiers

PMID41275162
PMCPMC12752316

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.