Observational studyBMC cancer2025
Demographic, clinicopathological, and treatment of oral squamous cell carcinoma patients at a Johannesburg Academic Hospital, South Africa: a 5-year retrospective observational study.
Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Treatment Patterns and Survival Outcomes of Oral Cavity Squamous Cell Carcinoma in Ethiopia: A Retrospective Study From Tikur Anbessa Specialized Hospital.Clinical Medicine Insights. Oncology · 2026Article
- Association ofInternational journal of medical sciences · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral squamous cell carcinoma (OSCC) comprises most oral malignancies worldwide and is closely associated with modifiable risk factors such as tobacco and alcohol use. Late-stage presentation is common and contributes significantly to poor treatment outcomes. This study aimed to delineate demographic, clinicopathological features, and radiation-induced toxicities among OSCC patients treated at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) between 2014 and 2019.
methodsA retrospective, cross-sectional review of 119 histologically confirmed OSCC cases was conducted. Data included patient demographics, tumour characteristics, alcohol consumption and smoking, treatment modality, and acute radiation-related toxicities. Descriptive statistics and inferential analyses were performed using SPSS version 24.0. Associations between categorical variables were tested using chi-square and Fisher's exact tests; p-values < 0.05 were considered statistically significant.
resultsAmong 119 patients, 71% were male (n = 84) with a mean age of 59.6 years. Black African patients constituted 67% of the cohort. The tongue (30%) and floor of mouth (25%), others were the most common tumour subsites. Most tumours were moderately differentiated (53%), and over 85% presented with stage III or IV disease. Tobacco use was reported in 94% of males and 66% of females, with alcohol use in 73% and 49%, respectively. A significant association was found between combined substance use and higher-grade tumours (p = 0.04). All patients experienced at least one radiation-induced toxicity, with mucositis (61%) and dermatitis (62%) being most frequent. Toxicities were significantly more prevalent in patients receiving concurrent chemoradiotherapy (p < 0.01).
conclusionThe study highlights the predominance of advanced-stage OSCC in older males with high-risk habits and underscores the urgent need for early detection strategies and public health interventions. High toxicity rates necessitate enhanced patient education and supportive care during treatment.
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