Evidence map›Paper›PMID 41275068›Full record

ArticleMolecular imaging and biology2026

First-in-Human Biodistribution and Dosimetry of [

Anthony J Young, Robert K Doot, Joshua K Cho, Jonathan M Pham, Alvaro A Ordonez, Andres F Del Castillo, Tiffany L Dominguez, Supritha Dugyala, Erin K Schubert, Hsiaoju Lee and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anthony J YoungDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Robert K DootDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Joshua K ChoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Jonathan M PhamDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Alvaro A OrdonezDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Andres F Del CastilloDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Tiffany L DominguezDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Supritha DugyalaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Erin K SchubertDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Hsiaoju LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Austin R PantelDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
David A MankoffDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA.
Mark A SellmyerDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 813 A Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA, 19104-6059, USA. mark.sellmyer@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-1407-1905

Funding

Burroughs Wellcome Fund CAMSIntramural Research Program, National Institute on Drug Abuse K01DA040023NIBIB NIH HHS 5-T32-EB004311-19NIH Office of the Director DP5-OD26386
6 · The paper itself

Abstract

Trimethoprim (TMP) is a reversible inhibitor of the prokaryotic enzyme dihydrofolate reductase (DHFR) used for the treatment or prophylaxis of bacterial infections. [

methodsFour males with suspected infection, aged 59 ± 10 years old (mean ± SD) received 3 serial PET/CT scans after injection of 346 ± 305 MBq (range 129-797 MBq) of [

results[

conclusion[

Indexed as

Carbon RadioisotopesRadiometryTrimethoprimAgedHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyTissue DistributionCarbon-11Carbon RadioisotopesTrimethoprimBiodistributionDosimetryInfectionPET/CTReporter geneTrimethoprim

Identifiers

PMID41275068
PMCPMC12966202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.