Evidence map›Paper›PMID 41275058›Full record

ArticleCellular and molecular life sciences : CMLS2025

ALKBH5 demethylation modification of SE-lncRNA ZMIZ1-AS1 promotes FGFR1-mediated proliferation and invasive metastasis in osteosarcoma.

Yuanzhuang Zhang, Yeqiu Xu, Yuxin Bao, Hanjie Zhai, Chenghao Li, Hongchao Shi, Fu Ren, Yong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuanzhuang ZhangSecond Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi, Shenyang, Liaoning, 110024, P.R. China.
Yeqiu XuSecond Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi, Shenyang, Liaoning, 110024, P.R. China.
Yuxin BaoSecond Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi, Shenyang, Liaoning, 110024, P.R. China.
Hanjie ZhaiSecond Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi, Shenyang, Liaoning, 110024, P.R. China.
Chenghao LiSecond Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi, Shenyang, Liaoning, 110024, P.R. China.
Hongchao ShiSecond Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi, Shenyang, Liaoning, 110024, P.R. China.
Fu RenKey Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province, Shenyang Medical College, Shenyang, Liaoning, 110000, P.R. China. rf@symc.edu.cn.
Yong WangSecond Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi, Shenyang, Liaoning, 110024, P.R. China. wy_smc@163.com.ORCID http://orcid.org/0000-0002-0979-8835

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81972522Liaoning Provincial Department of Education Science and Technology Platform Construction Project LJ232410164004
6 · The paper itself

Abstract

Osteosarcoma is the most prevalent primary malignant bone tumor in children and adolescents. However, its underlying pathogenesis and mechanisms driving metastasis remain poorly understood. Here, we identified a novel super-enhancer-associated long noncoding RNA (SE-lncRNA), Zinc Finger MIZ-Type Containing 1 Antisense RNA 1 (ZMIZ1-AS1), which is highly expressed in osteosarcoma and promoted tumor cell proliferation, migration, and invasion. Mechanistically, the m⁶A demethylase ALKBH5 post-transcriptionally stabilized ZMIZ1-AS1 through m⁶A demethylation. Furthermore, ZMIZ1-AS1 directly bound to the RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1), facilitating the translocation of PTBP1 from the nucleus to the cytoplasm. The relocalized PTBP1 then bound to and stabilized fibroblast growth factor receptor 1 (FGFR1) mRNA. In nude mouse models, ZMIZ1-AS1 overexpression promoted tumor growth and lung metastasis. Notably, combined inhibition of ALKBH5 (using ALKBH5-IN-5) and FGFR1 (using BGJ398/infigratinib) synergistically suppressed ZMIZ1-AS1-driven oncogenesis in vivo. Our study establishes the ALKBH5/ZMIZ1-AS1/PTBP1/FGFR1 signaling axis as a key driver of osteosarcoma progression and a promising target for therapeutic intervention.

Indexed as

AlkB Homolog 5, RNA DemethylaseBone NeoplasmsOsteosarcomaReceptor, Fibroblast Growth Factor, Type 1RNA, Long NoncodingAnimalsCell Line, TumorCell MovementCell ProliferationDemethylationGene Expression Regulation, NeoplasticHeterogeneous-Nuclear RibonucleoproteinsHumansMiceMice, Inbred BALB CMice, NudeALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseFGFR1 protein, humanHeterogeneous-Nuclear RibonucleoproteinsPolypyrimidine Tract-Binding ProteinPTBP1 protein, humanReceptor, Fibroblast Growth Factor, Type 1RNA, Long NoncodingALKBH5FGFR1FOSL1OsteosarcomaPTBP1Super-enhancerZMIZ1-AS1

Identifiers

PMID41275058
PMCPMC12799900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.