ArticleDiabetologia2026
Time-dependent association between progression of arterial stiffness and risk of incident chronic kidney disease: a cohort study in China.
Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Clinical Relevance and Potential Applications of Brachial-Ankle Pulse Wave Velocity: Current Evidence and Future Perspectives.Journal of clinical medicine · 2026Review
- Association of resting heart rate trajectories with incident chronic kidney disease in patients with hypertension.Clinical hypertension · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
aims/hypothesisThe relationship between the progression of arterial stiffness and the risk of chronic kidney disease (CKD) remains unclear. This study aimed to evaluate the time-dependent association between the progression of arterial stiffness and the risk of CKD.
methodsWe followed 10,567 individuals in the Kailuan Study, who were free of CKD and CVD at baseline. Arterial stiffness was repeatedly measured by brachial-ankle pulse wave velocity (baPWV) from baseline to the subsequent follow-ups. Time-dependent Cox models were used to estimate the association between progression of arterial stiffness (△baPWV/years) and incident CKD, defined as an eGFR below 60 ml/min per 1.73 m
resultsDuring a mean follow-up of 5.32 years, 1108 participants developed CKD. Lower quintiles in baPWV at baseline and the progression of baPWV over time were associated with a lower risk of CKD in a dose-dependent manner (p-trend <0.001). Compared with participants with the greatest deterioration in arterial stiffness (quintile 5), those with the greatest improvement in arterial stiffness (quintile 1) had a 45% (95% CI 34, 55) lower risk of CKD. Each SD increment in the progression of baPWV was associated with a 19% higher risk of CKD. Additionally, compared with participants who consistently had high baPWV (≥1400 cm/s), participants who maintained low baPWV (<1400 cm/s) or improved from high to low baPWV over time had a 46% (95% CI 33, 57) or 32% (95% CI 12, 48) lower risk of incident CKD, respectively. Adding progression of arterial stiffness to the CKD risk model modestly improved discrimination (optimism-adjusted C statistic from 0.690 to 0.709, p<0.001). CONCLUSIONS/
interpretationIn this cohort study, improvement in arterial stiffness, as indicated by a consistently low or decreased baPWV, might be associated with a lower risk of CKD. These findings underscore the potential importance of coordinated actions targeting cardiovascular health to improve kidney health in the general population.
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