ArticleCommunications medicine2025
Mpox due to monkeypox virus clade Ia infection detected outside of Africa: a case study.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- A Successful Cross-Agency Model for Collaborative Response to Imported Infectious Disease: Investigation and Management of the First Confirmed Clade Ia Mpox Case in Shanghai, China.Tropical medicine and infectious disease · 2026Article
- Epidemiology and characteristics of cases with monkeypox virus clade I in the WHO European Region, 2024 to 2025.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Nosocomial transmission in a monkeypox virus clade Ib outbreak, Ireland, August to October 2025.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMonkeypox virus clade Ia has historically been restricted to central Africa and primarily associated with zoonotic transmission. In February 2025, a symptomatic adult with recent travel to the Democratic Republic of the Congo presented to a tertiary care facility in Ireland and was subsequently diagnosed with monkeypox virus clade Ia infection. We describe the clinical, laboratory, phylogenetic and epidemiologic features of this case.
methodsDiagnostic testing was performed on the 5th of February using real-time polymerase chain reaction. The patient was admitted to the National Isolation Unit, and comprehensive contact tracing with active surveillance was implemented. Whole-genome sequencing was performed to determine the viral lineage and conduct phylogenetic and mutation analyses.
resultsThe patient experiences a stable disease course and recovers without long-term complications. No secondary transmission is detected. Genomic analysis confirms infection with monkeypox virus clade Ia. The sequence clusters within the recently documented sh2024a outbreak in Kinshasa and displays APOBEC3-associated mutational signatures consistent with sustained human-to-human transmission.
conclusionsThis case highlights changes in the global epidemiology of monkeypox virus clade Ia and underscores the need for enhanced surveillance and coordinated international public health responses. Early detection and monitoring by whole-genome sequencing are essential for mitigating the risks posed by possible expansion beyond traditionally endemic areas.
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Registered trials
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