Evidence map›Paper›PMID 41274981›Full record

ArticleScientific reports2025

The local anesthetic, lidocaine, suppresses the growth of colon cancer SW480 cells by decreasing the voltage-gated sodium channel subunit Na

Keiko Haraguchi-Suzuki, Toru Suzuki, Chigusa Nakasone, Reika Kawabata-Iwakawa, Shigeru Saito

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keiko Haraguchi-SuzukiIntensive Care Unit, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, 371-8511, Gunma, Japan. keiko.suzuki8@gunma-u.ac.jp.
Toru SuzukiDivision of RNA and Gene Regulation, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Chigusa NakasoneIntensive Care Unit, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, 371-8511, Gunma, Japan.
Reika Kawabata-IwakawaDivision of Integrated Oncology Research, Initiative for Advanced Research, Gunma University, Maebashi, Japan.
Shigeru SaitoDepartment of Anesthesiology, Gunma University Hospital, Maebashi, Japan.

Funding

Grants-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science 24K12086
6 · The paper itself

Abstract

Lidocaine is an inhibitor of voltage-gated sodium channels (VGSCs) expressed in excitable cells, such as myocardial cells and sensory neurons, and is used in many clinical situations, including as an anti-arrhythmic and analgesic agent. Clinical studies have suggested that its perioperative application in cancer patients improves their prognosis. Na

Indexed as

Anesthetics, LocalColonic NeoplasmsLidocaineNAV1.5 Voltage-Gated Sodium ChannelCell Line, TumorCell ProliferationCyclin D1Gene Expression Regulation, NeoplasticHumansTumor Suppressor Protein p53Anesthetics, LocalCyclin D1LidocaineNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanTumor Suppressor Protein p53Colon cancerLidocaineLocal anestheticNav1.5SCN5AVoltage-gated sodium channel

Identifiers

PMID41274981
PMCPMC12749173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.