ArticleScientific reports2025
BDNF plasmid hydrogel promotes neuroprotection and neurogenesis in rats with intracerebral hemorrhage.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Combined Stromal Vascular Fraction and HGF-Functionalized Self-Assembling Peptide Hydrogel Improves Intracerebral Hemorrhage Repair in Rats.Gels (Basel, Switzerland) · 2026Article
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9 authors.
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Abstract
Intracranial hemorrhage (ICH) remains a challenging disease worldwide with high mortality, morbidity, and disability. The combination of brain-derived neurotrophic factor (BDNF) therapy and hydrogel implantation is a potential novel treatment for promoting neuroprotection, neurogenesis, and neurological recovery. Hydrogel may serve as a vector for gene delivery. This study examined the therapeutic efficacy of BDNF plasmid delivered with a chitosan-based self-healing hydrogel in treating ICH rats. Direct injection of BDNF plasmid-containing hydrogel into bled brain tissue caused an approximately 1.8-fold increase in BDNF expression and behavioral improvements of at least 80%. Furthermore, medical imaging revealed that untreated rats experienced approximately 6% brain atrophy, while BDNF plasmid-treated rats showed reduced atrophy of 2%. Postmortem histological examination revealed that compared to untreated rats, rats treated with BDNF had a five fold increase in the number of neuroblasts, whereas the number of macrophages decreased by half. Conclusively, injection of self-healing hydrogel with BDNF plasmid may be a novel gene therapy approach for post-ICH treatment.
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