ArticleScientific reports2025
hsa_circ_0001818 regulates the function of macrophages in sepsis by inhibiting miR-17-3p, miR-433-3p, and miR-642a-5p.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dental pulp stem cell-derived exosomes attenuate psoriatic inflammation by restoring epithelial redox homeostasis via a miR-1246/miR-17-3p-GPX2-NF-κB axis.Stem cell research & therapy · 2026Article
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5 authors.
Funding
Abstract
Sepsis is a leading cause of death due to severe infections. Macrophages are important players in regulating the development of sepsis. Notably, hsa_circ_0001818 is highly expressed in the serum exosomes of sepsis patients and has shown potential as a diagnostic marker for the condition. However, its regulatory role in sepsis remains unclear. Here, we reported that hsa_circ_0001818 expression in macrophages is increased in sepsis. After hsa_circ_0001818 silencing, the apoptotic rate and release of inflammatory cytokines decreased, while phagocytic function of macrophages increased. In contrast, after hsa_circ_0001818 overexpression, the apoptotic rate and the release of inflammatory factors increased, whereas phagocytic function of macrophages decreased. In addition, mechanistic studies and rescue experiments confirmed that hsa_circ_0001818 adsorbs miR-17-3p, miR-433-3p, and miR-642a-5p as sponges, competitively inhibiting the expression of downstream target genes and regulating macrophage function. That is, hsa_circ_0001818 increased the apoptosis rate of macrophages through the miR-17-3p/caspase-3 (CASP3) axis, inhibited the phagocytic function of macrophages by adsorbing miR-433-3p and miR-642a-5p, and increased the secretion level of macrophage inflammatory factors by regulating the zinc finger and BTB domain-containing 20 (ZBTB20)/nuclear factor kappa-B (NF-κB) axis through miR-433-3p and miR-642a-5p. This study revealed the important role of hsa_circ_0001818 in sepsis and provided a new theoretical basis for the precise treatment of sepsis.
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