ArticlePediatric research2026
Umbilical cord blood markers predict neonatal hypoglycemia in full-term small and large for gestational age infants.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal hypoglycemia in small for gestational age (SGA) and large for gestational age (LGA) infants can lead to neurological complications. Predictive factors including umbilical cord blood analysis, remain largely unexplored.
methodsWe retrospectively investigated umbilical cord blood parameters as potential predictors of hypoglycemia in full-term SGA (n = 90) and LGA (n = 105) infants. Blood glucose was measured at 11 timepoints over 72 h. Hypoglycemia was defined as blood glucose <40 mg/dL.
resultsHypoglycemia occurred in 13.3% of SGA and 14.3% of LGA infants, with all episodes occurring within the first 2 h of life. In SGA infants, cord blood glucose <69 mg/dL predicted hypoglycemia with 83% sensitivity, 59% specificity, and 96% negative predictive value (NPV); area under the curve (AUC) 0.78, 95% confidence interval (CI): 0.66-0.89. In LGA infants, cord blood bicarbonate >23.1 mmol/L showed 73% sensitivity, 54% specificity, 92% NPV; AUC 0.67, 95% CI: 0.52-0.82, though with marginal statistical significance after multiple comparison correction.
conclusionDistinct cord blood markers reflect different pathophysiological mechanisms in SGA and LGA infants. While the glucose threshold <69 mg/dL provides a clinically applicable prediction for SGA infants, bicarbonate findings in LGA infants require prospective validation before clinical implementation. IMPACT: This study identifies distinct umbilical cord blood parameters as predictors of hypoglycemia in SGA and LGA infants. The findings reveal different pathophysiological mechanisms of hypoglycemia between SGA and LGA infants. Lower cord blood glucose levels predict hypoglycemia in SGA infants with good accuracy (AUC 0.78), while higher bicarbonate levels show potential association with hypoglycemia risk in LGA infants requiring validation. These group-specific markers could contribute to optimizing the frequency and timing of glucose monitoring strategies tailored to individual risk profiles.
Indexed as
Identifiers
41274962What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.