Evidence map›Paper›PMID 41274949›Full record

ArticleScientific reports2025

Zinc complex with quinoline-based thiazolyl-hydrazone targeting DNA replication in cancer cells.

Natalia Maciejewska, Јоvana Araškov, Mateusz Olszewski, Aleksandar Višnjevac, Nenad Filipović, Magdalena Stevanović, Berta Barta Holló, Tamara Todorović, Nenad Filipović

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalia MaciejewskaDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza St 11/12, 80-233, Gdansk, Poland. natalia.maciejewska@pg.edu.pl.
Јоvana AraškovFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11000, Serbia.
Mateusz OlszewskiDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza St 11/12, 80-233, Gdansk, Poland.
Aleksandar VišnjevacDivision of Physical Chemistry, Institute Ruđer Bošković, Bijenička cesta 54, 10000, Zagreb, Croatia.
Nenad FilipovićGroup for Biomedical Engineering and Nanobiotechnology, Institute of Technical Sciences of SASA, Kneza Mihaila 35/IV, Belgrade, 11000, Serbia.
Magdalena StevanovićGroup for Biomedical Engineering and Nanobiotechnology, Institute of Technical Sciences of SASA, Kneza Mihaila 35/IV, Belgrade, 11000, Serbia.
Berta Barta HollóUniversity of Novi Sad-Faculty of Sciences, Trg Dositeja Obradovića 4, Novi Sad, 21000, Serbia.
Tamara TodorovićFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11000, Serbia.
Nenad FilipovićFaculty of Agriculture, University of Belgrade, Nemanjina 6, Belgrade, 11000, Serbia. nenadf@agrif.bg.ac.rs.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of selective anticancer agents remains a central objective in medicinal chemistry. Here, we report the synthesis, structural characterization, and biological evaluation of the first metal complex of a quinoline-based thiazolyl-hydrazone ligand [(E)-2-(8-(quinolin-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole)] (HL). Obtained octahedral Zn(II) complex [Zn(HL)

Indexed as

Antineoplastic AgentsCoordination ComplexesDNA ReplicationHydrazonesQuinolinesThiazolesZincA549 CellsAnimalsApoptosisCell Line, TumorCell ProliferationHCT116 CellsHEK293 CellsHumansAntineoplastic AgentsCoordination ComplexesHydrazonesquinolineQuinolinesThiazolesZincAnticancer activityApoptosisDNA damageHydrazonyl-thiazolesQuinoline derivatives

Identifiers

PMID41274949
PMCPMC12663193

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.