Photocatalytic generation of amidine carbon radicals for aminodihydroquinoline synthesis.

Xin Yao, Jiaye Yu, Gaoting Lin, Huan Mei, Kui Zhang, Lingchao Cai

Abstract read

In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin YaoState Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing, China.

Jiaye YuState Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing, China.

Gaoting LinState Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing, China.

Huan MeiDepartment of Medical Mycology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.

Kui ZhangState Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing, China. zhangkui@njfu.edu.cn.

Lingchao CaiState Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing, China. cailingchao@njfu.edu.cn.ORCID http://orcid.org/0000-0001-9038-2724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amidines are ubiquitous in medicines and natural products. However, robust synthetic access to a broad spectrum of diverse analogues remains challenging due to the intrinsic limitations of the two-electron (2e) pathway. To overcome these synthetic constraints, we seek to develop a variant that generates amidine carbon radical as a common chemical synthon based on a one-electron (1e) pathway, remodeling retro-synthetical analysis for amidine-containing compounds. Herein, we present a mild, modular, and practical photocatalytic system tailored for assembling the highly privileged amidine pharmacophore. By ingeniously combining thiourea with PPh

Identifiers

PMID41274903

DOI10.1038/s41467-025-66701-z

PMCPMC12749265

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.