Evidence map›Paper›PMID 41274896›Full record

ArticleNature communications2025

A SARS-CoV-2 M

Seong Cheol Min, Jin-Ju Seo, Ju Hwan Jeong, Beom Kyu Kim, Ji-Hyun Park, Ju Ryeong Lee, Dong Gyu Lee, Gi Chan Lee, Se Hee An, Yun Hee Baek and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Seong Cheol Min *Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.ORCID http://orcid.org/0000-0001-8262-990X
Jin-Ju Seo *Technological Convergence Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Ju Hwan JeongDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.
Beom Kyu KimDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.ORCID http://orcid.org/0000-0003-4344-3488
Ji-Hyun ParkDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.
Ju Ryeong LeeDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.
Dong Gyu LeeDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.
Gi Chan LeeDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.
Se Hee AnDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.
Yun Hee BaekDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.
Young Ki ChoiCenter for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-0872-0147
Hyunah ChooMedicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Hyo Yong ParkMedicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.ORCID http://orcid.org/0009-0004-5050-0326
Gyeongmin KimMedicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Byungsun JeonMedicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Sang Chul ShinTechnological Convergence Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea. scshin84@kist.re.kr.ORCID http://orcid.org/0000-0003-0156-680X
Min-Suk SongDepartment of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea. songminsuk@chungbuk.ac.kr.ORCID http://orcid.org/0000-0001-6073-0783

Funding

Korea Health Industry Development Institute (KHIDI) RS-2024-00512595Ministry of Health, Welfare and Family Affairs | Korea Centers for Disease Control & Prevention (KCDC) 6634-325-320-01National Research Foundation of Korea (NRF) RS-2020-NR049557National Research Foundation of Korea (NRF) RS-2021-NR059195
6 · The paper itself

Abstract

SARS-CoV-2 variants resistant to current antivirals remain a significant threat, particularly in high-risk patients. Although nirmatrelvir and ensitrelvir both target the viral 3CL protease (M

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug Resistance, ViralSARS-CoV-2AnimalsChlorocebus aethiopsCOVID-19CricetinaeHumansIndazolesLactamsLeucineMaleMesocricetusMutation3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesensitrelvirIndazolesLactamsLeucinenirmatrelvirNitrilesProlineTriazinesTriazoles

Identifiers

PMID41274896
PMCPMC12663368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.