ArticleNPJ Parkinson's disease2025
Depending on intensity, exercise improved or worsened pathology in a model of prodromal Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Targeting GPCR Signaling in Parkinson's Disease: From Molecular Pathology to Exercise-Based Therapeutics.Molecular neurobiology · 2026Review
- Neurobiology of exercise in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Exercise suppresses apoptosis for alleviating Parkinson's disease: effects on pathophysiological molecular pathways.Frontiers in aging neuroscience · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise is increasingly applied as non-pharmacological intervention in Parkinson's disease (PD). While evidence suggests beneficial effects, the mechanisms, optimal intensity, and potential risks remain unclear. This study investigated the effects of treadmill exercise on motor and non-motor symptoms, alpha-synuclein pathology, neuroinflammation, and gut microbiota composition in Thy1-aSyn transgenic mice, a model of prodromal PD. Moderate (5 m/min) or intensive (12.5-15 m/min) treadmill exercise three times a week for one month delayed motor deficits, with improvements in beam-walking performance and gait coordination. Intensive training attenuated anxiety-like behavior and reduced phosphorylated alpha-synuclein accumulation in the substantia nigra, but not in limbic regions, demonstrating region-specific pathology modulation. Despite absent baseline neuroinflammation, intensive exercise increased microglial reactivity in the amygdala and hippocampus. Additionally, exercise increased fecal microbiota diversity across genotypes, with selective enrichment of Lachnospiraceae. These findings suggest that exercise modulates PD-related pathology and motor symptoms, although intensity-dependent limbic microgliosis warrants further investigation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.