Evidence map›Paper›PMID 41274668›Full record

ArticleBMJ health & care informatics2025

Continuous wireless sensor monitoring with applied diagnostics: Clinical Sensor Pain Scale and Automated Sensor Pain Scale in the NICU.

Susan Slattery, Sara Pessano, Jaeyoung Yoo, Yayun Du, Seyong Oh, Hyoyoung Jeong, John Mascari, Beth F Lappin, Hannah Alvarez, Tracey M Stewart and 8 more

Abstract read
In one paragraph

Article in BMJ health & care informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Susan SlatteryDivision of Neonatology, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA sslattery@luriechildrens.org.ORCID http://orcid.org/0000-0003-1894-0044
Sara PessanoPediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Jaeyoung YooQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois, USA.
Yayun DuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois, USA.
Seyong OhDivision of Electrical Engineering, Hanyang University - ERICA Campus, Ansan, The Republic of Korea.
Hyoyoung JeongElectrical and Computer Engineering Department, UC Davis College of Engineering, Davis, California, USA.
John MascariDivision of Neonatology, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Beth F LappinAutonomic Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Hannah AlvarezAutonomic Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Tracey M StewartAutonomic Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Kenny KronforstDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Erin LonerganAutonomic Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Joely GendlerAutonomic Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Casey RandAutonomic Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Narayanan KrishnamurthiAutonomic Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Aaron HamvasDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
John RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois, USA.
Debra Weese-MayerDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInappropriately treated pain can have deleterious outcomes in infants. Current tools rely on intermittent, subjective observation requiring specialised paediatric skills. This study aimed to diagnose infant pain through continuous monitoring with wireless sensors using Neonatal Pain and Agitation Sedation Scale (NPASS)-derived Clinical Sensor Pain Scale (CSPS) and Automated SPS (ASPS).

methodsClinically stable neonatal intensive care unit infants undergoing phlebotomy were recorded with wireless sensors and video, capturing vital signs, extremity movement and vocalisations. Clinicians and non-clinicians scored the sensor data with CSPS and videos with NPASS; ASPS was applied to the sensor data. Median scores were compared, inter-rater reliability assessed with intraclass correlation coefficients (ICC) and cross-scale comparisons performed using Wilcoxon signed-rank and Kruskal-Wallis tests.

resultsCSPS and ASPS closely aligned with NPASS scores, supporting their validity for continuous infant pain assessment. In 32 infants, the median CSPS score was 3 (IQR 2, 5), with excellent reliability (ICC, 95% CI 92 to 97), high internal consistency (Cronbach's α=0.99) and 95% absolute agreement, comparable to NPASS (p=0.95). Clinician and non-clinician scores were more consistent using CSPS than NPASS. ASPS also performed well, with a median score of 3 (IQR 1, 5), yielding results similar to CSPS (p=0.94) and NPASS (p=0.56).

conclusionsWireless biosensors enabled objective monitoring of infant pain. CSPS and ASPS showed validity and reliability for diagnosing acute procedural pain, and feasibility for clinical use. Findings support the development of automated, real-time tools to reduce subjectivity and improve infant pain management, with the potential to advance treatment models and outcomes.

Indexed as

Intensive Care Units, NeonatalPainPain MeasurementWireless TechnologyFemaleHumansInfant, NewbornMaleMonitoring, PhysiologicPhlebotomyReproducibility of Resultsartificial intelligencemachine learningmedical informatics applicationspain managementsignal processing, computer-assisted

Identifiers

PMID41274668
PMCPMC12658508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.