ArticleEpilepsy research2026
Allostatic load of immune cells in the spleen and brain of the Kcna1-null mouse model of temporal lobe epilepsy.
Jillian E Hinman, Ankita Aggarwal, Amberlee Haggerty, Stephanie A Matthews, Malavika Deodhar, Shruthi Iyer, Kristina A Simeone, Timothy A Simeone
Abstract read
In one paragraphArticle in Epilepsy research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Jillian E HinmanDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Ankita AggarwalDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Amberlee HaggertyDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Stephanie A MatthewsDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Malavika DeodharDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Shruthi IyerDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Kristina A SimeoneDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA. Electronic address: KristinaSimeone@Creighton.edu.
Timothy A SimeoneDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA. Electronic address: TimothySimeone@Creighton.edu.
Funding
Autoresuscitation and SUDEPR01NS126418 · NINDS · CREIGHTON UNIVERSITY · PI Kristina A Simeone, Timothy A. Simeone · 2022 to 2026
$1.7MPPARgamma, Epilepsy and TherapeuticsR01NS085389 · NINDS · CREIGHTON UNIVERSITY · PI SIMEONE, TIMOTHY A. · 2014 to 2018
$1.5MReplacing an Animal Resource Facility Cage Washer.G20RR024001 · NCRR · CREIGHTON UNIVERSITY · PI DRESCHER, KRISTEN · 2007 to 2007
$638kThe Role of the Adaptive Immune System in EpilepsyR21NS114741 · NINDS · CREIGHTON UNIVERSITY · PI SIMEONE, KRISTINA A, SIMEONE, TIMOTHY A. · 2021 to 2021
$383kNCRR NIH HHS G20 RR024001NINDS NIH HHS R01 NS085389NINDS NIH HHS R01 NS126418NINDS NIH HHS R21 NS114741
6 · The paper itselfAbstract
Human temporal lobe epilepsy (TLE), particularly drug-resistant TLE, is associated with chronic peripheral immune activation. Here, we determined whether a similar association was detectable in a genetic mouse model of TLE with spontaneous recurrent seizures (SRS), Kcna1-null mice. Flow cytometry was used with fluorescence-activated cell sorting to determine the presence of lymphocytes, macrophages and granulocytes in isolated brain and spleen of wildtype (WT) and Kcna1-null mice. Splenic analysis revealed uniformly elevated Mac-1
Indexed as
AllostasisBrainEpilepsy, Temporal LobeKv1.1 Potassium ChannelSpleenAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutKcna1 protein, mouseKv1.1 Potassium ChannelAllostasisEpilepsyInflammationKv1.1LymphocytesMacrophageT cells
Identifiers
PMID41274174
PMCPMC12857741
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