Article in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
21 authors.
Eunji ChoiDepartment of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.ORCID 0000-0003-1315-1433
Wanting ZhaiDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC, United States.
Jaeil AhnDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC, United States.ORCID 0000-0001-7998-4759
Tim A AhlesDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, United States.ORCID 0000-0002-7936-2818
Ashley L ArteseDepartment of Exercise Science and Health Promotion, Charles E. Schmidt College of Science, Florida Atlantic University, Boca Raton, FL, United States.ORCID 0000-0001-8811-566X
Iwalola AwoyinkaDepartment of Psychiatry and Behavioral Medicine, MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, United States.ORCID 0000-0003-0536-0550
Judith E CarrollSemel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0000-0001-5516-0819
Harvey J CohenCenter for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, United States.
Kathleen Van DykSemel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0000-0003-1500-930X
Deena GrahamJohn Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, United States.ORCID 0000-0003-1111-6984
Heather S L JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, United States.ORCID 0000-0001-7353-3711
Brenna C McdonaldDepartment of Radiology and Imaging Sciences, Melvin and Bren Simon Comprehensive Cancer Center, and Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID 0000-0001-6895-4490
Zev M NakamuraDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.ORCID 0000-0001-9695-1457
Sunita K PatelDepartment of Supportive Care Medicine, City of Hope Comprehensive Cancer Center, Duarte, CA, United States.ORCID 0000-0002-9023-8391
Kelly E RentscherDepartment of Psychiatry and Behavioral Medicine, MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, United States.ORCID 0000-0003-1887-3953
James C RootDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, United States.ORCID 0000-0001-7332-6165
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Melvin and Bren Simon Comprehensive Cancer Center, and Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID 0000-0002-1376-8532
Brent J SmallSchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.ORCID 0000-0002-7444-4689
Yiwey ShiehDepartment of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.ORCID 0000-0002-0159-7748
Jeanne S MandelblattInstitute for Cancer and Aging REsearch (I-CARE) and Cancer Prevention and Control Program at Georgetown Lombardi Comprehensive Cancer Center and Departments of Oncology and Medicine at Georgetown University School of Medicine, Georgetown University, Washington, DC, United States.ORCID 0000-0002-2490-005X
Traci N BetheaDepartment of Oncology, Georgetown University, Washington, DC, United States.ORCID 0000-0003-3205-2078
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WANG, SOPHIA · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINER01CA129769 · NCI · GEORGETOWN UNIVERSITY · PI AHLES, TIM ALAN, MANDELBLATT, JEANNE · 2009 to 2020
$7.3M
Bio-behavioral Research At The Intersection of Cancer and AgingR35CA197289 · NCI · GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE · 2015 to 2021
$6.2M
Social Determinants of Health as Transducers of Cellular Aging: A New Multi-level Paradigm to Reduce Survivorship Disparities at the Intersection of Cancer and AgingR35CA283926 · NCI · GEORGETOWN UNIVERSITY · PI Jeanne Mandelblatt · 2023 to 2026
$3.7M
Patterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related DementiasR01AG082348 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Judith E Carroll, Jeanne Mandelblatt · 2023 to 2026
$3.3M
Mobile Device CBT for Chemotherapy-Related Cognitive Dysfunction: A Multi-Center Randomized Controlled TrialR01CA244673 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FERGUSON, ROBERT J, MCDONALD, BRENNA C · 2020 to 2024
$3.0M
I-REACH (Infrastructure for REsearch on Cancer and Aging)R33AG075008 · NIA · GEORGETOWN UNIVERSITY · PI Lucile L. Adams-Campbell, Judith E Carroll · 2024 to 2026
$2.3M
Biobehavioral Oncology Training ProgramT32CA269115 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Jennifer Mary KNIGHT, Melinda R Stolley · 2023 to 2026
$1.2M
Heterogeneity in biological, physical, and cognitive aging in older breast cancer survivors and controlsR56AG068086 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARROLL, JUDITH E, MANDELBLATT, JEANNE · 2021 to 2021
$886k
An assessment of whether aspirin and/or vitamin D improves breast cancer outcomes in Black women and the modifying effect of genetic variantsK01CA212056 · NCI · GEORGETOWN UNIVERSITY · PI BETHEA, TRACI N. · 2017 to 2021
backgroundNeighborhood characteristics can affect aging and health. We tested the effects of neighborhood deprivation on deficit accumulation frailty scores in a prospective cohort of breast cancer survivors vs control individuals aged 60 to 98 years.
methodsNewly diagnosed, nonmetastatic breast cancer survivors (n = 477) and frequency-matched control individuals (n = 434) were enrolled between 2010 and 2023, with up to 5-year follow-up through 2024. Deficit accumulation was measured using a 48-item index (scores of 0-1); a clinically meaningful deficit increase was defined by a 0.06 score increase. Neighborhood deprivation was assessed using the Area Deprivation Index (ADI) at enrollment census block group and categorized into tertiles. Cause-specific Cox models tested the association between ADI and risk of deficit accumulation increase.
resultsParticipants living in more deprived areas (second and third tertiles of ADI) had a higher risk of increased deficit accumulation (adjusted hazard ratios = 1.38, 95% CI = 1.01 to 1.89, P = .04 and 1.46, 95% CI = 1.07 to 1.94, P = .01 vs first tertile, respectively). Independent of ADI, being a survivor (vs a control individual) was associated with greater risk of increased deficit accumulation (adjusted hazard ratio = 1.69, 95% CI = 1.32 to 2.17, P < .001). Patterns of cumulative incidence rates of increased deficit accumulation differed by ADI: Survivors treated with chemotherapy (with or without hormone therapy) living in more vs less deprived areas had a 20% higher incidence of increased deficit accumulation within 1 year (P = .004), while survivors receiving hormone therapy alone and noncancer control individuals had their most pronounced differences by 4 years (10%, P = .32 and 10%, P = .05, respectively).
conclusionsNeighborhood deprivation may increase deficit accumulation, with an apparent acceleration of effects among older (≥60 years of age) breast cancer survivors treated with chemotherapy.
Indexed as
Breast NeoplasmsCancer SurvivorsFrailtyNeighborhood CharacteristicsResidence CharacteristicsAgedAged, 80 and overCase-Control StudiesFemaleHumansMiddle AgedProspective Studies
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Neighborhood deprivation on increasing deficit accumulation in older breast cancer survivors and noncancer control individuals. · full record | OpenQuestion