Evidence map›Paper›PMID 41273693›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

The Comet Assay in Nano-ecogenotoxicology.

Patrizia Guidi, Giada Frenzilli

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patrizia GuidiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Giada FrenzilliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. giada.frenzilli@unipi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comet assay is a quick and versatile technique for assessing DNA damage in individual cells. It allows the detection of DNA single- and double-strand breaks, as well as the presence of alkali-labile sites and cross-links. Here we describe protocols for the Single-Cell Gel Electrophoresis (Comet assay) in its alkaline (pH > 13), mild alkaline (pH = 12.1), and neutral (pH = 8) versions when applied in aquatic animals exposed to nanomaterials.

Indexed as

Comet AssayDNA DamageNanostructuresAnimalsHydrogen-Ion ConcentrationSingle-Cell AnalysisAquatic animalsComet assayDNA strand breaksGillsHemocytesNanomaterialsNanoparticlesSingle-Cell Gel electrophoresis

Identifiers

PMID41273693

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.