Evidence map›Paper›PMID 41273665›Full record

ArticleDermatology and therapy2026

Is Cumulative Life Course Impairment Considered in Psoriasis Management? A Multinational Survey of People with Psoriasis and Healthcare Professionals.

Raymond Matthews, April W Armstrong, Matthias Augustin, Christopher Baker, José Manuel Carrascosa, Brian Kirby, Richard Langley, Sandy McBride, Adam Reich, Ricardo Romiti and 2 more

Abstract read
In one paragraph

Article in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raymond MatthewsDermatology Centre, Northern Care Alliance NHS Foundation Trust and Division of Musculoskeletal and Dermatological Sciences, Manchester NIHR Biomedical Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. raymond.matthews@manchester.ac.uk.ORCID https://orcid.org/0000-0003-3449-4451
April W ArmstrongDivision of Dermatology, University of California Los Angeles, Los Angeles, USA.ORCID https://orcid.org/0000-0003-0064-8707
Matthias AugustinInstitute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg, Hamburg, Germany.ORCID https://orcid.org/0000-0002-4026-8728
Christopher BakerVincent's Hospital Melbourne, University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0009-0003-0144-2927
José Manuel CarrascosaServicio de Dermatología Hospital Universitari Germans Trias I Pujol (HUGiT), Universitat Autònoma de Barcelona, Badalona, Spain.ORCID https://orcid.org/0000-0003-4266-0771
Brian KirbyUniversity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-7596-892X
Richard LangleyDalhousie University and Nova Scotia Health, Halifax, Canada.ORCID https://orcid.org/0000-0003-4730-2164
Sandy McBrideRoyal Free London NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-8449-1809
Adam ReichDepartment of Dermatology, Medical College of Rzeszów, University, Rzeszów, Poland.ORCID https://orcid.org/0000-0002-5573-1754
Ricardo RomitiDepartment of Dermatology, University of São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0003-0165-3831
Francesca SampognaClinical Epidemiology Unit, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-7624-3290
Richard B WarrenDermatology Centre, Northern Care Alliance NHS Foundation Trust and Division of Musculoskeletal and Dermatological Sciences, Manchester NIHR Biomedical Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-2918-6481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDelays remain in patients receiving effective treatment strategies that have potential to clear their skin of psoriasis, improve their quality of life (QoL) and change the psoriatic disease course, which, if uncontrolled, can irreversibly alter an individual's life course (i.e. cumulative life course impairment [CLCI]). This study explored current international awareness and consideration of the potential impact of psoriasis over the life course within clinical assessments and decisions about its management.

methodsCross-sectional surveys collated insights from people with psoriasis and healthcare professionals (HCPs) treating psoriasis (dermatologists and primary care physicians [PCPs]) across 29 countries.

resultsData were collected from 487 people with psoriasis, 574 dermatologists and 618 PCPs. Despite people with psoriasis highlighting a range of daily activities that are 'very frequently' or 'always' affected by their psoriasis, 37% were never or rarely asked by their HCPs how the disease affects their life. Fewer than half of people with psoriasis had a high understanding of the potential future impact of psoriasis (or CLCI-contributing factors), and 44% were unaware that clear/almost clear skin is now a realistic treatment target. Almost half of HCPs considered psoriasis to be of early onset when it presented at ≤ 15 years of age. Despite HCP awareness of the impact of psoriasis on QoL, many of the contributing factors to CLCI were not addressed routinely in clinical practice nor considered when deciding on treatment; 40% of dermatologists set treatment goals (such as clear skin/almost clear skin/target Dermatology Life Quality Index [DLQI]) sometimes, less frequently, or not at all.

conclusionsMisalignment exists in the experience of people living with psoriasis versus its assessment in clinical practice. Support is needed for assessment and monitoring of elements that may contribute to CLCI in clinical practice worldwide, to guide early psoriasis treatment decision-making to mitigate the risk for CLCI. Infographic available for this article. INFOGRAPHIC.

Indexed as

CLCIClinical managementCross-sectionLifePatient experiencePsoriasis

Identifiers

PMID41273665
PMCPMC12872985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.