Evidence map›Paper›PMID 41273557›Full record

ReviewAdvances in experimental medicine and biology2026

The Potential of Exhaled Breath Analysis for Alzheimer's Disease Monitoring (mini review).

S Patsiris, T Exarchos, P Vlamos

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In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S PatsirisGeneral Hospital of Corfu, Corfu, Greece.
T ExarchosDepartment of Informatics, Ionian University, Corfu, Greece.
P VlamosDepartment of Informatics, Ionian University, Corfu, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction-Alzheimer's disease is a neurodegenerative disease and the main type of dementia. It has multifactorial pathogenesis and is characterized by delayed diagnosis. Both affect the management. Research on various specimens and metabolic products of the processes involved in its development is ongoing, with the aim of understanding its pathomechanisms. A promising medium that is believed to help in this regard is exhaled breath.Methods-We reviewed the published literature on exhaled breath and its association with Alzheimer's disease. Results-Alterations in the exhaled breath profile of patients with Alzheimer's disease compared to healthy individuals were observed. There are two studies that reported differences in the concentrations of specific volatile organic compounds in exhaled breath between patients with Alzheimer's disease and healthy individuals. Moreover, discrimination between different stages of Alzheimer's disease was achieved by studying the profile of the exhaled breath. It seems that Alzheimer's and Parkinson's diseases also have different exhaled breath profiles. It is worth mentioning that various methods and equipment were used in the studies, limiting the direct comparison of the results. Conclusion-It seems that the study of the exhaled breath can contribute to the diagnosis, discrimination, and monitoring of Alzheimer's disease. Further research with larger scales and more common protocols is needed.

Indexed as

Alzheimer DiseaseVolatile Organic CompoundsBiomarkersBreath TestsDiagnosis, DifferentialDisease ProgressionEarly DiagnosisHumansParkinson DiseaseBiomarkersVolatile Organic CompoundsAlzheimer’s diseaseDiagnosisExhaled breathMonitoringPathogenesis

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.