Evidence map›Paper›PMID 41273548›Full record

ArticleAdvances in experimental medicine and biology2026

Cerebral Arterial Stiffness Dynamics During Acute Stage of Severe Traumatic Brain Injury.

Alex O Trofimov, Ekaterina Volkova, Edwin M Nemoto, Olga A Bragina, Denis E Bragin

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Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Alex O TrofimovDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation.
Ekaterina VolkovaDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation.
Edwin M NemotoDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Olga A BraginaLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Denis E BraginDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to assess the dynamics of cerebral arterial stiffness based on cerebral arterial compliance (CAC) changes during the acute stage of severe traumatic brain injury (sTBI). MATERIALS AND

methodsWe examined 75 patients with severe TBI (men 52 and women 23). During or immediately after dynamic computed tomography angiography (DCTA), the monitoring of the transcranial Doppler of the MCA was recorded bilaterally with 2-MHz probes in the first days after trauma (first control point) and in 10-14 days of acute stage of sTBI (second control point). The cerebral blood volumes were calculated from the DCTA data using complex mathematical procedures using the "direct flow model" algorithm. Data were normally distributed and expressed as mean ± standard deviation. The statistical analysis was performed using parametric statistics and correlation analysis methods. The level of significance was p < 0.05.

resultsCAC was significantly decreased (p < 0.001) in both the control points. The stiffness of middle cerebral arteries significantly (p < 0.05) increases in the first days and stays increased during all acute stages of severe TBI. The CAC was significantly correlated with CBF (r = -0.161, p < 0.05).

Indexed as

Brain Injuries, TraumaticCerebral ArteriesMiddle Cerebral ArteryVascular StiffnessAdultAgedCerebrovascular CirculationComputed Tomography AngiographyFemaleHumansMaleMiddle AgedUltrasonography, Doppler, TranscranialYoung AdultCerebral arterial compliancePerfusion CTSevere traumatic brain injury

Identifiers

PMID41273548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.