Evidence map›Paper›PMID 41273533›Full record

ArticleAnnals of the New York Academy of Sciences2026

Cardiovascular Activity Predominantly Modulates Brain Dynamics in Non-REM Sleep Transitions.

Vincenzo Catrambone, Ugo Faraguna, Gaetano Valenza

Abstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vincenzo CatramboneNeurocardiovascular Intelligence Laboratory & Department of Information Engineering & Bioengineering and Robotics Research Center, E. Piaggio, School of Engineering, University of Pisa, Pisa, Italy.
Ugo FaragunaDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Pisa, Italy.
Gaetano ValenzaNeurocardiovascular Intelligence Laboratory & Department of Information Engineering & Bioengineering and Robotics Research Center, E. Piaggio, School of Engineering, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the brain-heart axis and its directional control dynamics across various sleep stages using electroencephalography and electrocardiogram data from publicly available whole-night recordings of 50 healthy individuals. Utilizing a validated functional brain-heart interplay (BHI) mathematical model, we identified a decrease in central control over peripheral neural activity regulating heartbeat dynamics during non-REM sleep. In contrast, an increase in sympathovagal activity influencing cortical function was observed during deep sleep, particularly in Non-REM3, compared to light sleep and REM phases. These results indicate a dynamic shift in the functional balance of the brain-heart axis and related BHI throughout sleep stages, characterized by predominant central control during wakefulness and enhanced bodily neuro-cardiac-autonomic regulation during deep sleep.

Indexed as

BrainSleepSleep StagesAdultElectrocardiographyElectroencephalographyFemaleHeartHeart RateHumansMaleSleep, REMWakefulnessYoung Adultbrain–heart interplayelectroencephalographyheart rate variabilitysleepsleep stages

Identifiers

PMID41273533
PMCPMC12836467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.