Molecularly Imprinted Polymer-Based Electrochemical Chiral Sensors.

Given the pharmacologically distinct actions of enantiomers in living systems, chiral recognition is a key feature of many biological molecules and is a significant research area in pharmaceutical analysis. The chiral molecules in question (one or a mixture of enantiomers) and the selector must specifically interact for the sensor to provide an enantio-differentiating signal. Typically, at least three binding centers regulate this kind of interaction. By engaging with one of the enantiomers and arranging themselves mutually, these centers successfully govern the selectivity of recognition. The creation of three-dimensional cavities with customized recognition capabilities is made possible by the unique potential offered by molecular imprinting technology. This topic has had significant disciplinary expansion lately, giving rise to innovative transduction strategies and a wide range of possible applications. The current cutting-edge approaches in chiral recognition using molecularly imprinted polymers (MIPs) may pave the way for the design of new chiral sensors.This chapter discusses the advantages and disadvantages of the designed sensors during the optimization phase and their analytical performance. Also, notes and suggestions about the situations encountered during the experiment are presented.