Evidence map›Paper›PMID 41273488›Full record

ArticleMetabolic brain disease2025

Lactobacillus fermentum ATCC 9338 ameliorates immune dysregulation via indoleamine 2, 3-dioxygenase through modulating gut microbial diversity of chronic unpredictable mild stressed mouse.

Sneha Tiwari, Vijay Paramanik

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sneha TiwariCellular and Molecular Neurobiology and Drug Targeting Laboratory, Department of Zoology, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, 484 887, India.ORCID 0000-0001-6253-2609
Vijay ParamanikCellular and Molecular Neurobiology and Drug Targeting Laboratory, Department of Zoology, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, 484 887, India. vijay.paramanik@igntu.ac.in.ORCID 0000-0002-8394-8010

Funding

Indian Council of Medical Research 2021-11643University Grants Commission 2021
6 · The paper itself

Abstract

Gut microbiota (GM) plays a significant role in the pathophysiology of neuropsychiatric diseases like depression. A complex two-way system between gut and brain termed as gut-brain axis (GBA) dependent on intestinal GM and central nervous system (CNS). Alterations in the GM can affect behavior and brain neurochemistry including tryptophan metabolism through immune mediated pathways. Researchers focused to understand immune challenges involving kynurenine action via indoleamine-2,3-dioxygenase (IDO) induces depressive like "sickness behavior". This study examined the role of Lactobacillus fermentum (LF) and 1-methyl-D-tryptophan (1-MT) on IDO regulation, proinflammatory cytokine responses, and gut microbial diversity in chronic unpredictable mild stress (CUMS) depression model. LF (oral administration, 1 × 10

Indexed as

Gastrointestinal MicrobiomeIndoleamine-Pyrrole 2,3,-DioxygenaseLimosilactobacillus fermentumProbioticsStress, PsychologicalAnimalsBrainCytokinesDepressionMaleMiceMice, Inbred C57BLTryptophan1-methyltryptophanCytokinesIndoleamine-Pyrrole 2,3,-DioxygenaseTryptophan1-Methyl-D-tryptophanDepressionGut microbiotaLactobacillus fermentumNeuroinflammationProinflammatory cytokines

Identifiers

PMID41273488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.