Evidence map›Paper›PMID 41273482›Full record

ArticleGeroScience2026

Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male mice.

Ramkumar Thiyagarajan, Rupadevi Muthaiah, Bhavana Sreevelu, Owen P Treanor, Yonas Redae, Reem Berman, Anna L Davis, Nanda Yellapu, Spencer R Rosario, Lee D Chaves and 2 more

Abstract read
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ramkumar ThiyagarajanDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Rupadevi MuthaiahDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Bhavana SreeveluDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Owen P TreanorDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Yonas RedaeDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Reem BermanDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Anna L DavisDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Nanda YellapuICMR-Vector Control Research Center, Indira Nagar Medical Complex, Puducherry, India.
Spencer R RosarioDepartment of Biostatistics and Bioinformatics and Experimental Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Lee D ChavesDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Kenneth L SeldeenDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA.
Bruce R TroenDivision of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA. btroen@kumc.edu.ORCID http://orcid.org/0000-0002-3699-0021

Funding

Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize HealthspanK07AG060266 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI TROEN, BRUCE R. · 2019 to 2023
$774k
BLRD VA I01 BX000758BLRD VA I01 BX004369National Institute of Health 5K07AG06026602NIA NIH HHS K07 AG060266U.S. Department of Veterans Affairs BX000758
6 · The paper itself

Abstract

Cognitive impairment affects 1 in 6 individuals over 60, with over 75 million projected by 2030. Age-related changes in microglial function and declining nicotinamide adenine dinucleotide (NAD

Indexed as

AgingCognitionCognitive DysfunctionMicrogliaNiacinamidePyridinium CompoundsAnimalsCognitive EnhancementDietary SupplementsMaleMaze LearningMiceMice, Inbred C57BLNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsAgingCognition declineDisease-associated microgliaMicrogliaNAD metabolism

Identifiers

PMID41273482
PMCPMC13601472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.