Evidence map›Paper›PMID 41273462›Full record

ArticleMolecular neurobiology2025

Caenorhabditis Elegans Ortholog of TNF Alpha-Induced Protein 1 is Upregulated by TOL-1 and Exacerbates Amyloid-Beta-Associated Pathology.

Yanmei Su, Donghua Zhang, Yixin Li, Huan Gu, Wenhu Li, Wenhui Zhou, Ninghui Zhao, Xiaowei Huang

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanmei Su *School of Medicine, Yunnan University, Kunming, 650091, China.
Donghua Zhang *Southwest Forestry University, Forestry College, Kunming, 650224, China.
Yixin LiSchool of Medicine, Yunnan University, Kunming, 650091, China.
Huan GuSchool of Medicine, Yunnan University, Kunming, 650091, China.
Wenhu LiNeurosurgery of the Second Hospital Affiliated With Kunming Medical University, Kunming, 650101, China.
Wenhui ZhouSchool of Medicine, Yunnan University, Kunming, 650091, China.
Ninghui ZhaoNeurosurgery of the Second Hospital Affiliated With Kunming Medical University, Kunming, 650101, China. zhaoninghui@kmmu.edu.cn.
Xiaowei HuangSchool of Medicine, Yunnan University, Kunming, 650091, China. xwhuang@ynu.edu.cn.

Funding

Natural Science Foundation Program of China No. 32170184Yunnan Fundamental Research Projects No. 202403AC100007Yunnan University Graduate Research Innovation Fund KC-23236341
6 · The paper itself

Abstract

Neuroinflammation has been recognized as a central pathological mechanism in Alzheimer's disease (AD), modulated by diverse molecular pathways. Among these, the tumor necrosis factor superfamily (TNFSF) pathway serves as a pivotal mediator of inflammatory responses in higher organisms, representing a potential therapeutic target for AD treatment. Notably, TNF alpha-induced protein 1 (TNFAIP1) is significantly upregulated following amyloid-beta

Indexed as

Amyloid beta-PeptidesCaenorhabditis elegansCaenorhabditis elegans ProteinsToll-Like ReceptorsUp-RegulationAlzheimer DiseaseAnimalsAnimals, Genetically ModifiedHumansAmyloid beta-PeptidesCaenorhabditis elegans ProteinsToll-Like ReceptorsAlzheimer’s diseaseCaenorhabditis elegansMitochondrial homeostasisMolecular mechanism of pathogenesisTNFSF pathwayToll-like receptor

Identifiers

PMID41273462

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.