ReviewClinical oral investigations2025
Potential interference of the herpes simplex virus with periodontal regeneration: a narrative review.
Review in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesThis narrative review aimed to critically examine the potential impact of herpes simplex virus-1 (HSV-1) on periodontal regenerative therapy by synthesizing current evidence from in vitro studies on human periodontal ligament (PDL) cells and the limited available clinical data. Particular emphasis was placed on how HSV-1 infection alters cellular behavior and inflammatory responses in PDL cells, thereby potentially impairing periodontal regeneration. MATERIALS AND
methodsWe conducted a structured literature review to identify original research articles investigating HSV-1 infection in human PDL cells and clinical studies assessing HSV infection in the context of periodontal regenerative therapy. The inclusion criteria were limited to studies that directly addressed the effects of HSV on PDL biology or regenerative outcomes.
resultsThree recent in vitro studies have demonstrated that HSV-1 infects PDL cells, inducing cytopathic effects and amplifying inflammatory cytokine production. These effects are exacerbated in pro-inflammatory microenvironments. A single clinical study suggested that HSV-1-positive patients exhibit poorer outcomes following regenerative periodontal surgery. However, the clinical evidence remains limited and exploratory in nature.
conclusionsAlthough current clinical data are scarce, our in vitro findings suggest that HSV-1 compromises the regenerative potential of PDL cells through direct infection and inflammatory modulation. Further translational and longitudinal clinical studies are needed to clarify this relationship. CLINICAL RELEVANCE: Recognizing the viral influence on periodontal regeneration may help guide the future development of antiviral adjuncts and personalized regenerative strategies, especially for patients with latent HSV infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.