Trial reportClinical oral investigations2025
Concentrated growth factors for closure of oroantral communications after tooth extraction: A randomized controlled clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Acute Oroantral Communication Closure: Resorbable Collagen Membrane vs. Buccal Advancement Flap Outcomes: A Clinical Trial.Journal of functional biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo investigate the efficacy of concentrated growth factors (CGF) in the repair of oroantral communications (OAC), especially in the repair of bone tissue. MATERIALS AND
methodsThirty patients with OAC defects measuring 3-5 mm were randomly assigned to either the CGF group (CGF repair, n = 15) or the control group (suture repair, n = 15). At 1, 3 and 7 days postoperatively, patients recorded pain intensity by a 10-point visual analogue scale (VAS). Soft tissue healing was evaluated using a modified version of the Mass Healing Index at 7 and 30 days postoperatively. The success rate of the oroantral communications defect closure was assessed at 30 days postoperatively. Cone-beam computed tomography (CBCT) scans were performed before and 90 days after surgery, while radiographic analyses were used to evaluate the height, volume, and density of new bone. Data were compared using t tests or Mann‒Whitney U tests, with statistical significance set at P < 0.05 for all analyses.
resultsPatients in the CGF group reported significantly lower pain scores on Days 1 and 3 postoperatively compared to the control group (P = 0.049, P = 0.0122); however, comparable pain was observed in both groups at 7 days after the operation. The CGF group showed significantly better healing scores on Day 7 (p = 0.0148), while a healing effect was observed in both groups at 30 days postoperatively. Both groups achieved a 100% OAC closure success rate. The CGF group demonstrated superior new bone height, volume, and density (P < 0.05).
conclusionCGF use for OAC repair demonstrated benefits for soft and hard tissue healing in extraction sockets and postoperative pain, providing a simple, minimally invasive, and highly successful option for OAC repair following tooth extraction. CLINICAL RELEVANCE: The CGF repair method provides a novel treatment approach for OAC with defects measuring 3-5 mm, particularly when implant restoration is necessary in the later stages of the lesion tooth area.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.