ReviewResults and problems in cell differentiation2026
Hydra at the Crossroads of Evolution: Insights into Cell-type Diversification, Regeneration, and Epigenetic Regulation.
Review in Results and problems in cell differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Understanding the origins of cellular complexity and dynamics of gene regulatory modules is critical to gain insights into the multicellular organization in eumetazoan evolution. Positioned at the base of Eumetazoa, cnidarians such as Hydra offer crucial insights into these fundamental processes due to their unique combination of simple body plans and complex biological capabilities. Their key phylogenetic position allows researchers to trace the emergence of cell types such as neurons, gland cells, and germ cells, and also specialized cell types such as cnidocytes from common progenitor populations. Hydra has been known as a popular model system for studying its extraordinary regeneration process. This has enabled the understanding of the axis formation and cellular reprogramming, making it a valuable model for studying morphogenesis, patterning, and cellular plasticity. Moreover, Hydra exhibits conserved and dynamic epigenetic mechanisms, such as DNA methylation, histone modifications, and noncoding RNAs, which regulate gene expression across different cell types and during regeneration. Collectively, these features make Hydra an ideal system to investigate the evolution of cell types, the interplay between regeneration and developmental signaling, and the origins of epigenetic regulation in early multicellular life. Here, we synthesize existing knowledge to offer new perspectives and highlight the expanded potential of Hydra as a model system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.