Observational studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Loss of muscle and bone mass with increased adiposity and fractures in patients with chronic obstructive pulmonary disease: A 5-year follow-up cohort study.
Observational study in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Author's reply to: "COPD, sarcopenia and fractures: integrating musculoskeletal risk into respiratory care".Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
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Authors and funding
5 authors.
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Abstract
Musculoskeletal fragility in Chronic obstructive pulmonary disease (COPD) is often overlooked. Using an observational cohort of COPD patients followed over five years, a higher fracture rate was observed alongside significant loss of bone and muscle mass, as well as increased fat mass index. PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with a higher risk of sarcopenia and fractures. We aim to assess changes in body composition and bone mineral density (BMD), and the occurrence of fractures in patients with COPD from a tertiary hospital.
methodsForty patients with COPD (mean age 69.0 ± 7.5 years; 21 women) who joined the cohort at baseline (November 2013 to December 2015) were reevaluated after a median follow-up of 58 months (final assessment). BMD, appendicular lean mass (ALM), body fat (BF), and fat mass index (FMI) were measured using DXA, along with spine radiography with vertebral morphometry at both assessments.
resultsThere was a significant increase in the rates of vertebral (22.5% versus 38.5%; P = 0.031) and non-vertebral (12.5% versus 17.5%; P < 0.001) fractures. Half of the fractures occurred in patients with a BMD T-score > -2.5. Notable decreases were observed in ALM (17.5 ± 4.0 versus 16.5 ± 4.1 kg/m
conclusionOver a 5-year follow-up, COPD patients experience a significant loss of BMD and lean mass, along with increased adiposity and fractures.
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