Evidence map›Paper›PMID 41273342›Full record

ArticleExperimental physiology2026

Impaired nitric oxide-dependent endothelial function in young male individuals with obesity before the onset of symptoms and complications.

Lucrezia Zuccarelli, Giovanni Baldassarre, Adele Bondesan, Diana Caroli, Roberta De Micheli, Gabriella Tringali, Thomas Favaretto, Joanna Suraj-Prazmowska, Anna Kurpinska, Joanna Majerczak and 4 more

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lucrezia ZuccarelliDepartment of Medicine, University of Udine, Udine, Italy.ORCID https://orcid.org/0000-0003-2447-4684
Giovanni BaldassarreDepartment of Medicine, University of Udine, Udine, Italy.ORCID https://orcid.org/0000-0002-4182-9216
Adele BondesanExperimental Laboratory for Auxo-endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo-Verbania, Italy.
Diana CaroliExperimental Laboratory for Auxo-endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo-Verbania, Italy.
Roberta De MicheliExperimental Laboratory for Auxo-endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo-Verbania, Italy.
Gabriella TringaliExperimental Laboratory for Auxo-endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo-Verbania, Italy.
Thomas FavarettoDepartment of Medicine, University of Udine, Udine, Italy.
Joanna Suraj-PrazmowskaJagiellonian Center for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland.
Anna KurpinskaJagiellonian Center for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland.
Joanna MajerczakChair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
Stefan ChlopickiJagiellonian Center for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland.
Jerzy A ZoladzChair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.ORCID https://orcid.org/0000-0002-1143-5590
Alessandro SartorioExperimental Laboratory for Auxo-endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo-Verbania, Italy.
Bruno GrassiDepartment of Medicine, University of Udine, Udine, Italy.ORCID https://orcid.org/0000-0003-3188-1659

Funding

'Central (cardiorespiratory) and peripheral (muscular) determinants of functional deterioration in COPD: new biomarkers for evaluating disease severity and acute exacerbations?'Italian Ministry of Health - ricerca correnteJagiellonian University Collegium Medicum N43/DBS/000221Jagiellonian University Collegium Medicum N43/DBS/000315'Long-COVID syndrome: pathophysiology of the impaired exercise tolerance'Ministero dell'Istruzione dell'Università e della Ricerca 2020EM9A8XMinistero dell'Istruzione dell'Università e della Ricerca 2022LBBKHXMinistero dell'Istruzione dell'Università e della Ricerca G53D23005610006Ministero dell'Istruzione dell'Università e della Ricerca G53D2300747000Ministero dell'Istruzione dell'Università e della Ricerca P2022XX7YLqLIFE Priority Research Area under the Excellence Initiative - Research University Programme at the Jagiellonian University 06/IDUB/2019/94
6 · The paper itself

Abstract

Endothelial dysfunction drives obesity-related complications. Doppler ultrasound measurement of blood flow during 1-min passive leg movements (PLM) is a valuable non-invasive tool for assessing endothelial function and nitric oxide (NO)-mediated vasodilation. The objectives of this work were t o identify endothelial dysfunction biomarkers in young individuals with obesity (OB) using the PLM test; to evaluate the effects of a rehabilitation programme on these biomarkers; and to explore associations between PLM data, oxidative metabolism and blood biomarkers of microvascular impairment. Fifteen male OB (age 17 ± 4 years; body mass 121.4 ± 24.1 kg; body mass index 39.3 ± 7.5 kg m

Indexed as

Endothelium, VascularNitric OxideObesityAdolescentBiomarkersExerciseHumansMaleOxygen ConsumptionRegional Blood FlowVasodilationYoung AdultBiomarkersNitric Oxideendothelial functionexercise tolerancenitric oxideobesityPLM

Identifiers

PMID41273342
PMCPMC12949103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.