Evidence map›Paper›PMID 41273158›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Fluoride-Transfer Asymmetric Allylic Alkylation Enables Regiodivergent, Stereoselective Cross-Electrophile Coupling.

Jordi Duran, Vyali Georgian Moldoveanu, Claudia Barroso, Geraldo Augusto Pereira, Bart Limburg, Xavier Companyó

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Palladium-catalyzed asymmetric carbofluorination ofChemical communications (Cambridge, England) · 2026
    Article
  2. AgBFChemical science · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordi DuranSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Carrer Martí i Franquès 1, Barcelona, 08028, Spain.
Vyali Georgian MoldoveanuSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Carrer Martí i Franquès 1, Barcelona, 08028, Spain.
Claudia BarrosoSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Carrer Martí i Franquès 1, Barcelona, 08028, Spain.
Geraldo Augusto PereiraSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Carrer Martí i Franquès 1, Barcelona, 08028, Spain.
Bart LimburgSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Carrer Martí i Franquès 1, Barcelona, 08028, Spain.
Xavier CompanyóSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Carrer Martí i Franquès 1, Barcelona, 08028, Spain.

Funding

European Union NextGenerationEU/PRTR CEX2021-001202-MEuropean Union NextGenerationEU/PRTR CNS-2022-135457European Union NextGenerationEU/PRTR CNS2023-144535European Union NextGenerationEU/PRTR PID2023-149005NB-I00MICIU/AEI/10.13039/501100011033
6 · The paper itself

Abstract

Asymmetric allylic alkylation (AAA) is a widely used strategy for stereoselective formation of C─C bonds. Yet, conventional methods often exhibit poor atom economy as the leaving group is generally wasted. Herein, we report a fluoride-transfer asymmetric allylic alkylation (AAA) in which all the atoms of the reagents are incorporated into the final products. The catalytic platform enables regiodivergent, stereoselective cross-electrophile coupling of allyl fluorides and gem-difluoroalkenes, where the regiochemical outcome is directed by the selective catalytic activation of one or the other electrophilic partner. The resulting atom-efficient AAA protocol provides a regiocontrollable access to homoallylic trifluoromethylated compounds from a common set of electrophilic starting materials.

Indexed as

Asymmetric allylic alkylationAsymmetric trifluoromethylationAtom economyCross‐electrophile couplingRegiodivergent catalysis

Identifiers

PMID41273158
PMCPMC12790306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.