Evidence map›Paper›PMID 41273157›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Characterisation of the N-Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines.

Benjamin Panagiotis Chapple, Lia Nitz, Pascal Schneider, Birgit Henßen, Sebastian Myllek, Mona Haase, Thomas Classen, Jörg Pietruszka

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benjamin Panagiotis ChappleInstitute for Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf am Forschungszentrum Jülich, Jülich, 52426, Germany.
Lia NitzInstitute for Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf am Forschungszentrum Jülich, Jülich, 52426, Germany.
Pascal SchneiderInstitute for Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf am Forschungszentrum Jülich, Jülich, 52426, Germany.
Birgit HenßenInstitute for Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf am Forschungszentrum Jülich, Jülich, 52426, Germany.
Sebastian MyllekInstitute for Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf am Forschungszentrum Jülich, Jülich, 52426, Germany.
Mona HaaseInstitute for Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf am Forschungszentrum Jülich, Jülich, 52426, Germany.
Thomas ClassenInstitute of Bio- and Geosciences (IBG-1: Bioorganic Chemistry), Forschungszentrum Jülich, Jülich, 52426, Germany.
Jörg PietruszkaInstitute for Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf am Forschungszentrum Jülich, Jülich, 52426, Germany.ORCID 0000-0002-9819-889X

Funding

European Regional Development Fund 34-EFRE-0300096European Regional Development Fund 34-EFRE-0300097German Federal Ministry of Education of Research 031B1134A
6 · The paper itself

Abstract

Many natural products and pharmaceutical compounds bear the pyrroloindoline scaffold, highlighting the importance of the heterocyclic motif. Here, we aim at expanding the toolset for the selective synthesis of pyrroloindolines by characterising and employing the N-methyltransferase SgPsmC from Streptomyces griseofuscus, an enzyme involved in the biosynthesis of physostigmine, in a selective kinetic resolution of pyrroloindolines performed at a laboratory preparative scale.

Indexed as

IndolesMethyltransferasesPyrrolesStreptomycesKineticsIndolesMethyltransferasesPyrrolesBiocatalysisEnzymesHeterocyclesKinetic resolution

Identifiers

PMID41273157
PMCPMC12790363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.