ArticleNucleic acids research2026
CircleBase V2: an eccDNA annotation platform across cancers and species.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The landscape and regulatory potential of eccDNAs in mammalian preimplantation embryos.Nature communications · 2026Article
- The 2026 Nucleic Acids Research database issue and the online molecular biology database collection.Nucleic acids research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
CircleBase V2 (http://circlebase2.maolab.org) is a comprehensive update of our previously developed database, offering a significantly expanded and functionally enhanced resource for investigating extrachromosomal circular DNA (eccDNA) in human and mouse. This version introduces several key advancements: (i) a 12-fold increase in eccDNA data, comprising over 7.4 million entries from >300 types of cell lines and tissues, providing broader coverage across diverse physiological and disease contexts; (ii) inclusion of mouse eccDNAs, with >3.6 million entries from over 20 tissues, enabling robust cross-species comparative analyses and enhancing translational research with mouse models; (iii) a dedicated motif discovery module that systematically identifies junction-specific sequence patterns, shedding light on molecular mechanisms underlying eccDNA formation; and (iv) an improved functional scoring framework that integrates multi-omic annotations, including chromatin accessibility, regulatory elements, genetic variants, and chromatin interactions, to help prioritize functionally relevant eccDNAs. Additionally, CircleBase V2 features an upgraded user interface with enhanced visualization tools, supporting flexible querying, batch downloads, and integrative analyses. Collectively, these advancements establish CircleBase V2 as an indispensable platform for uncovering the biological roles and regulatory functions of eccDNAs in cancer, development, and other diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.