ArticleBrain and behavior2025
Disrupted Practice Effects and Altered Prefrontal Activation in Mild Cognitive Impairment: An fNIRS Study Using the Stroop Task.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The Impact of Different Severities of Anxiety on Decision-Making.Brain and behavior · 2026Article
- Disrupted Practice Effects and Altered Prefrontal Activation in Mild Cognitive Impairment: An fNIRS Study Using the Stroop Task.Brain and behavior · 2025Article
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4 authors.
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Abstract
introductionExecutive dysfunction, particularly inhibitory control, is an early core symptom of mild cognitive impairment (MCI) and is often associated with altered prefrontal cortical activity. Repeated engagement in cognitive tasks may offer a means of assessing and potentially enhancing neural adaptability in these regions.
objectiveThis study examined how repeated Stroop task performance modulates executive function and prefrontal cortical activation in older adults with MCI, compared to cognitively healthy controls (HC), using functional near-infrared spectroscopy (fNIRS).
methodsA total of 37 older adults (17: MCI, 20: HC) completed three consecutive sessions of a computerized color-word Stroop task. Behavioral performance (reaction time) and hemodynamic responses (oxyhemoglobin, HbO) were recorded across predefined prefrontal regions of interest, including the ventrolateral prefrontal cortex (VLPFC), dorsolateral prefrontal cortex, orbitofrontal cortex, and frontopolar cortex.
resultsThe results demonstrated a significant improvement in response time and reduced HbO activation in the VLPFC across sessions in the HC group, suggesting enhanced cognitive efficiency and selective inhibition. By contrast, the MCI group demonstrated delayed and limited adaptation, with meaningful changes occurring only in the final session.
conclusionHealthy aging is associated with rapid neurofunctional adaptation to cognitive challenges, whereas individuals with MCI exhibit impaired plasticity in executive control circuits. fNIRS sensitively detects early executive deficits, supporting its potential for early diagnosis of cognitive impairment.
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