Evidence map›Paper›PMID 41272850›Full record

ArticleBreast cancer research : BCR2025

Genome-wide association study of Asian women identifies putative mammographic density-associated loci.

Shivaani Mariapun, Mikael Eriksson, Mei-Chee Tai, Nur Aishah Mohd Taib, Cheng Har Yip, Kartini Rahmat, Celine M Vachon, Sara Lindstrom, Jingmei Li, Mikael Hartman and 4 more

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Article in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Shivaani MariapunCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mei-Chee TaiCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Nur Aishah Mohd TaibUniversity Malaya Cancer Research Institute, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Cheng Har YipSubang Jaya Medical Centre, Subang Jaya, Malaysia.
Kartini RahmatBiomedical Imaging Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Celine M VachonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Sara LindstromDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Jingmei LiDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Mikael HartmanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Weang-Kee Ho *Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. weangkee.ho@nottingham.edu.my.
Soo-Hwang Teo *Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. soo.teo@gmail.com.

Funding

Malaysian Ministry of Higher Education High Impact Research Grant UM.C/HIR/MOHE/06Newton - Ungku Omar Fund MR/P012930/1Wellcome TrustWellcome Trust v203477/Z/16/Z
6 · The paper itself

Abstract

backgroundMammographic density (MD) is a strong, heritable risk factor for breast cancer. To date, 55 independent MD-associated genetic loci have been identified through genome-wide association studies (GWASs) in women of European ancestry; however, no studies have been reported in Asian women.

methodsTo identify novel loci, we conducted genome-wide association studies (GWASs) of absolute dense, absolute nondense, and percentage area and volumetric densities, adjusting for age, body mass index (BMI), and ancestry-informative principal components, in a multi-ethnic cohort of 2,951 Asian women attending opportunistic mammography screening. We selected 175 novel loci that were associated with at least one MD phenotype at P < 5 × 10

resultsFour of the 175 loci were replicated in women of Asian ancestry at P < 0.05, with directions of association that were consistent with those observed in the GWAS. The rs7018644 SNP at the 9p13.1 locus was the only loci replicated in both Asian and European cohorts. In addition, eight SNPs were also associated with breast cancer risk (P < 0.05) in a GWAS meta-analysis of Asian women.

conclusionThis study identifies potential novel MD-associated loci in Asian women. Replication in a larger Asian study is needed to confirm these findings.

Indexed as

Asian PeopleBreast DensityBreast NeoplasmsGenetic LociGenome-Wide Association StudyAdultAgedFemaleGenetic Predisposition to DiseaseHumansMammographyMiddle AgedPolymorphism, Single NucleotideRisk FactorsWhite PeopleAsianGWASMammographic density

Identifiers

PMID41272850
PMCPMC12639730

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