Evidence map›Paper›PMID 41272848›Full record

ArticleAlzheimer's research & therapy2025

Neuroinflammation PET and long-term cognition and survival in symptomatic Alzheimer's disease.

Roos M Rikken, Maqsood Yaqub, Emma M Coomans, Ellen Dicks, Anne E van der Vlies, Albert D Windhorst, Ronald Boellaard, Yolande A L Pijnenburg, Everard G B Vijverberg, Elsmarieke van de Giessen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roos M RikkenRadiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands. r.rikken@amsterdamumc.nl.
Maqsood YaqubRadiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Emma M CoomansAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, De Boelelaan 1118, Amsterdam, 1081HV , The Netherlands.
Ellen DicksAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, De Boelelaan 1118, Amsterdam, 1081HV , The Netherlands.
Anne E van der VliesAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, De Boelelaan 1118, Amsterdam, 1081HV , The Netherlands.
Albert D WindhorstRadiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Ronald BoellaardRadiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, De Boelelaan 1118, Amsterdam, 1081HV , The Netherlands.
Everard G B VijverbergAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, De Boelelaan 1118, Amsterdam, 1081HV , The Netherlands.
Elsmarieke van de GiessenRadiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.

Funding

Alzheimer Nederland WE.03-2021-04
6 · The paper itself

Abstract

backgroundNeuroinflammation plays a key role in Alzheimer's disease (AD) pathophysiology, but it is not clear how neuroinflammation contributes to disease progression. We aim to investigate the role of neuroinflammation on longitudinal cognition and survival in a unique cohort with PET imaging of translocator protein (TSPO) binding tracer [

methods19 participants with AD dementia, 9 participants with MCI due to AD, and 21 healthy controls (HC) with historical dynamic [

resultsTwo PCs were retained. PC1 explained 55.4% of the variance and was most explained by [

conclusionsContrary to our hypothesis, we did not find evidence for [

Indexed as

Alzheimer DiseaseBrainCognitionCognitive DysfunctionNeuroinflammatory DiseasesPositron-Emission TomographyAgedAged, 80 and overDisease ProgressionFemaleHumansIsoquinolinesLongitudinal StudiesMaleMiddle AgedIsoquinolinesPK 11195Alzheimer’s diseaseCognitionMicrogliaNeuroinflammationPET

Identifiers

PMID41272848
PMCPMC12751148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.