ArticleJournal of neuroinflammation2025
The heme-binding protein hemopexin promotes functional recovery and tissue protection after spinal cord injury via sex-specific regulation of inflammation and ferroptosis.
Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- miR-24-3p promotes spinal cord injury repair in rats by inhibiting ferroptosisNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- The ferroptosis-mediated domino effect: metabolic crosstalk from intervertebral disc degeneration to spinal deformity and cord injury: a mini review.Frontiers in neuroscience · 2026Review
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Authors and funding
8 authors.
Funding
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Abstract
In individuals with spinal cord injury (SCI), intraparenchymal hemorrhage is correlated with worsened functional recovery. Hemorrhage is a well described contributor to secondary tissue damage, which expands the tissue damage beyond the initial injury. Hence, targeting hemorrhage mediated secondary damage is critical for tissue preservation and neurological outcome. In this work, we investigate the role of hemopexin (Hx), an acute-phase plasma glycoprotein that sequesters the blood breakdown product heme, thus preventing toxicity and inflammation induced by intraparenchymal hemorrhage after SCI.In a mouse model of lower thoracic (T10/T11) spinal cord contusion injury, Hx and its receptor low-density lipoprotein receptor-related protein 1 (LRP-1), were significantly upregulated after SCI. Hx was detected predominantly in astrocytes, while LRP-1 was primarily colocalized with macrophages. The absence of Hx worsened locomotor recovery in male and female Hx
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