Evidence map›Paper›PMID 41272812›Full record

ReviewAdvances in rheumatology (London, England)2025

Juvenile idiopathic inflammatory myopathies assessment by magnetic resonance imaging: a scoping review of protocols, scoring systems, and applications.

Vitor Tavares Paula, Clarissa Harumi Omori, Samuel Katsuyuki Shinjo, Daniel Brito de Araújo, Jessica Day, Adam Schiffenbauer, Claudia Saad Magalhães, Edoardo Conticini, Edoardo Marrani, Julio Brandão Guimarães and 6 more

Abstract readScoping ReviewReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in rheumatology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Vitor Tavares Paula *Radiology Department, Children's Institute, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0005-1249-118X
Clarissa Harumi Omori *Pediatric Rheumatology Unit, Children's Institute, Hospital Das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0008-1771-3767
Samuel Katsuyuki ShinjoDivision of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-3682-4517
Daniel Brito de AraújoInternal Medicine Department, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, RS, Brazil.ORCID https://orcid.org/0000-0002-4840-945X
Jessica DayThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-8528-4361
Adam SchiffenbauerEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-9964-9966
Claudia Saad MagalhãesPediatric Rheumatology Unit, Department of Pathology, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Edoardo ConticiniRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0002-3974-6606
Edoardo MarraniRheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0002-0346-3268
Julio Brandão GuimarãesUniversidade Federal de São Paulo, EPM-UNIFESP, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5075-5896
Lisa G RiderEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6912-2458
Mickael EssoumaNetwork of Immunity in Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network, Yaounde, Cameroon.ORCID http://orcid.org/0000-0003-2364-5517
Simone AppenzellerDepartment of Orthopedics, Rheumatology and Traumatology, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0001-5075-4474
Andrea Schwarz Doria *Department of Diagnostic & Interventional Radiology, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-3202-0447
Adriana Maluf Elias *Pediatric Rheumatology Unit, Children's Institute, Hospital Das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. adriana.sallum@hc.fm.usp.br.ORCID https://orcid.org/0000-0003-0823-6459
IMACS WBMRI in Myopathies Working Group

Funding

Assessment, Therapy and Prevention Of Autoimmune DiseaseZIAES101081 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$17.6M
Assessment, Therapy and Prevention Of Autoimmune DiseaseZ01ES101081 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MILLER, FREDERICK · 2002 to 2008
$2.2M
Intramural NIH HHS Z01 ES101081Intramural NIH HHS ZIA ES101081
6 · The paper itself

Abstract

backgroundOur review assessed whole body (WB) and dedicated body-part magnetic resonance imaging (DedMRI) techniques, protocols, and inflammatory scoring systems, focusing on their clinimetric properties (reliability, validity, responsiveness) in clinical and research settings of patients with juvenile idiopathic inflammatory myopathies (JIIM).

methodsA comprehensive search of MEDLINE, EMBASE, and Cochrane databases from 2000 to 2024 identified relevant studies.

resultsSixteen studies enrolling JIIM patients with MRI were reviewed, which showed heterogeneity in objectives, methodologies, and scoring systems. Four (25%) studies used quantitative assessments, while 12 (75%) employed semi-quantitative or qualitative methods in scoring MRI. WB-MRI was performed in 3 (18.7%) studies, and DedMRI in 13 (81.2%). Muscle evaluation included assessments of edema [14 (87.5%) studies], fatty infiltration [4 (25%) studies], and atrophy [6 (37.5%) studies]. T1 images were used in 9 (56.2%) studies for measuring chronic changes, with coronal views reported in 6 (37.5%). Fluid-sensitive sequences (T2 with fat saturation, STIR) were employed in all studies and were obtained in the coronal plane in 9 (56.2%). These sequences were crucial for detecting soft tissue edema related to acute/subacute inflammation. One (6%) study included diffusion and T1 post-contrast sequences.

conclusionThere is significant heterogeneity in MRI protocols for evaluating JIIM. Standardized WB-MRI protocols are needed to ensure consistency and comparability across studies and institutions, optimize assessments of disease activity, treatment response, and follow-up in JIIM patients. Standardization should enhance the reliability of MRI for diagnosing and monitoring JIIM in clinical and research settings.

Indexed as

DermatomyositisMagnetic Resonance ImagingMyositisChildHumansMuscle, SkeletalReproducibility of ResultsSeverity of Illness IndexWhole Body ImagingIdiopathic inflammatory myopathyJuvenile dermatomyositisMagnetic resonance imagingMyositisScoping review

Identifiers

PMID41272812
PMCPMC12711408

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.